UniProt Accession

 ABD12_HUMAN; Q8N2K0; A6NED4; A6NJ90; A8K450; B4DE71; Q5T710; Q5T711; Q96CR1; Q9BX05; Q9NPX7; Q9UFV6 

Genbank Protein ID

 AK075023; AK290815; AK293495; AL121772; AL353812; AL121772; AL353812; AL353812; AL121772; AL353812; AL121772; CH471133; BC014049; AL117442 

Genbank Nucleotide ID

 BAC11357.1; BAF83504.1; BAG56982.1; CAI23474.1; CAI23474.1; CAI23475.1; CAI23475.1; CAI13762.1; CAI13762.1; CAI13763.1; CAI13763.1; EAX10089.1; AAH14049.1; CAB55927.1 

Protein Name

 Monoacylglycerol lipase ABHD12 

Protein Synonyms/Alias

 2-arachidonoylglycerol hydrolase; Abhydrolase domain-containing protein 12 

Gene Name

 ABHD12 

Gene Synonyms/Alias

 C20orf22 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
232	LHVFDWIKARSGDNP	ubiquitination	[1]
283	TNIREEAKSHPFSVI	ubiquitination	[1]
358	ARSFRDFKVQFVPFH	ubiquitination	[2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Has 2-arachidonoylglycerol hydrolase activity (By similarity). May be a regulator of endocannabinoid signaling pathways (By similarity). 

Sequence Annotation

 ACT_SITE 246 246 Charge relay system (By similarity).
 ACT_SITE 333 333 Charge relay system (By similarity).
 ACT_SITE 372 372 Charge relay system (By similarity).  

Keyword

 Alternative splicing; Cataract; Complete proteome; Deafness; Glycoprotein; Hydrolase; Membrane; Neuropathy; Polymorphism; Reference proteome; Retinitis pigmentosa; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 398 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0047372; F:acylglycerol lipase activity; IEA:EC. 

Interpro

 IPR026605; ABHD12. 

Pfam

  

SMART

  

PROSITE

  

PRINTS