UniProt Accession

 GBB1_RAT; P54311; Q6Q8B1; Q9QWG8 

Genbank Protein ID

 U34958; U88324; AY552805; BC078809 

Genbank Nucleotide ID

 AAC72249.1; AAD00650.1; AAS59143.1; AAH78809.1 

Protein Name

 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 

Protein Synonyms/Alias

 Transducin beta chain 1 

Gene Name

 Gnb1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
15	RQEAEQLKNQIRDAR	acetylation	[1]
89	WDSYTTNKVHAIPLR	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction. 

Sequence Annotation

 REPEAT 53 83 WD 1.
 REPEAT 95 125 WD 2.
 REPEAT 141 170 WD 3.
 REPEAT 182 212 WD 4.
 REPEAT 224 254 WD 5.
 REPEAT 268 298 WD 6.
 REPEAT 310 340 WD 7.
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 266 266 Phosphohistidine (By similarity).  

Keyword

 3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Phosphoprotein; Reference proteome; Repeat; Transducer; WD repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 340 AA 

Protein Sequence

Gene Ontology

 GO:0044297; C:cell body; IDA:RGD.
 GO:0030425; C:dendrite; IDA:RGD.
 GO:0005834; C:heterotrimeric G-protein complex; IDA:RGD.
 GO:0001917; C:photoreceptor inner segment; IDA:RGD.
 GO:0042622; C:photoreceptor outer segment membrane; IDA:RGD.
 GO:0003924; F:GTPase activity; IEA:Compara.
 GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW.
 GO:0010659; P:cardiac muscle cell apoptotic process; IDA:MGI.
 GO:0008283; P:cell proliferation; IEA:Compara.
 GO:0071456; P:cellular response to hypoxia; IDA:MGI.
 GO:0007204; P:elevation of cytosolic calcium ion concentration; IMP:RGD.
 GO:0007186; P:G-protein coupled receptor signaling pathway; IMP:RGD.
 GO:0007200; P:phospholipase C-activating G-protein coupled receptor signaling pathway; IEA:Compara.
 GO:0060041; P:retina development in camera-type eye; IEA:Compara.
 GO:0050909; P:sensory perception of taste; IEA:Compara. 

Interpro

 IPR020472; G-protein_beta_WD-40_rep.
 IPR001632; Gprotein_B.
 IPR016346; Guanine_nucleotide-bd_bsu.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 

Pfam

 PF00400; WD40 

SMART

 SM00320; WD40 

PROSITE

 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 

PRINTS

 PR00319; GPROTEINB.
 PR00320; GPROTEINBRPT.