UniProt Accession

 G3XA10_MOUSE; G3XA10 

Genbank Protein ID

 AC166710; CH466555 

Genbank Nucleotide ID

 EDL13177.1 

Protein Name

 Heterogeneous nuclear ribonucleoprotein U 

Protein Synonyms/Alias

 Heterogeneous nuclear ribonucleoprotein U, isoform CRA_b 

Gene Name

 Hnrnpu 

Gene Synonyms/Alias

 Hnrpu; mCG_17220 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
17	KLKVSELKEELKKRR	acetylation	[1, 2]
17	KLKVSELKEELKKRR	ubiquitination	[3]
21	SELKEELKKRRLSDK	acetylation	[2]
28	KKRRLSDKGLKADLM	acetylation	[2]
31	RLSDKGLKADLMDRL	acetylation	[1]
31	RLSDKGLKADLMDRL	ubiquitination	[3]
181	AGKEAAGKSSGPTSL	acetylation	[2]
181	AGKEAAGKSSGPTSL	ubiquitination	[3]
241	FEYIEENKYSRAKSP	acetylation	[1, 2, 4]
241	FEYIEENKYSRAKSP	ubiquitination	[3]
319	FEMKVTEKIPVRHLY	acetylation	[2]
319	FEMKVTEKIPVRHLY	succinylation	[2]
319	FEMKVTEKIPVRHLY	ubiquitination	[3]
328	PVRHLYTKDIDIHEV	acetylation	[1, 2, 4]
328	PVRHLYTKDIDIHEV	succinylation	[2]
328	PVRHLYTKDIDIHEV	ubiquitination	[3]
363	GYSLKGIKTCNCETE	ubiquitination	[3]
440	FNFGQKEKPYFPIPE	acetylation	[1]
440	FNFGQKEKPYFPIPE	ubiquitination	[3]
492	GKTTWVTKHAAENPG	acetylation	[1]
492	GKTTWVTKHAAENPG	ubiquitination	[3]
500	HAAENPGKYNILGTN	acetylation	[1]
500	HAAENPGKYNILGTN	ubiquitination	[3]
519	KMMVAGFKKQMADTG	acetylation	[1, 2]
519	KMMVAGFKKQMADTG	succinylation	[2]
527	KQMADTGKLNTLLQR	acetylation	[1, 2, 4]
527	KQMADTGKLNTLLQR	ubiquitination	[3]
541	RAPQCLGKFIEIAAR	acetylation	[1, 2, 4]
541	RAPQCLGKFIEIAAR	succinylation	[2]
541	RAPQCLGKFIEIAAR	ubiquitination	[3]
550	IEIAARKKRNFILDQ	ubiquitination	[3]
568	SAAAQRRKMCLFAGF	acetylation	[1]
578	LFAGFQRKAVVVCPK	acetylation	[1]
585	KAVVVCPKDEDYKQR	acetylation	[1]
602	KKAEVEGKDLPEHAV	acetylation	[2]
602	KKAEVEGKDLPEHAV	ubiquitination	[3]
611	LPEHAVLKMKGNFTL	acetylation	[1, 2]
611	LPEHAVLKMKGNFTL	succinylation	[2]
611	LPEHAVLKMKGNFTL	ubiquitination	[3]
640	LQKEEAQKLLEQYKE	ubiquitination	[3]
646	QKLLEQYKEESKKAL	acetylation	[1, 2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome; Ribonucleoprotein; Viral nucleoprotein; Virion. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 793 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0030529; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
 GO:0003676; F:nucleic acid binding; IEA:UniProtKB-KW. 

Interpro

 IPR001870; B30.2/SPRY.
 IPR008985; ConA-like_lec_gl_sf.
 IPR026745; hnRNP_U.
 IPR027417; P-loop_NTPase.
 IPR003034; SAP_dom.
 IPR018355; SPla/RYanodine_receptor_subgr.
 IPR003877; SPRY_rcpt. 

Pfam

 PF02037; SAP
 PF00622; SPRY 

SMART

 SM00513; SAP
 SM00449; SPRY 

PROSITE

 PS50188; B302_SPRY
 PS50800; SAP 

PRINTS