UniProt Accession

 Q3UGA8_MOUSE; Q3UGA8 

Genbank Protein ID

 AK148034 

Genbank Nucleotide ID

 BAE28301.1 

Protein Name

 Amidophosphoribosyltransferase 

Protein Synonyms/Alias

 ATase; Glutamine phosphoribosylpyrophosphate amidotransferase 

Gene Name

 Ppat 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
60	SDGSAVPKFRVHKGM	ubiquitination	[1]
220	PVSDVNDKEKKSSET	ubiquitination	[1]
372	RQLGVAKKFGVLSDN	ubiquitination	[1]
403	NTISPIIKLLKESGA	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

  

Sequence Annotation

 ACT_SITE 12 12 For GATase activity (By similarity).
 METAL 280 280 Iron-sulfur (4Fe-4S) (By similarity).
 METAL 426 426 Iron-sulfur (4Fe-4S) (By similarity).
 METAL 503 503 Iron-sulfur (4Fe-4S) (By similarity).
 METAL 506 506 Iron-sulfur (4Fe-4S) (By similarity).  

Keyword

 Glycosyltransferase; Iron; Iron-sulfur; Magnesium; Metal-binding; Purine biosynthesis; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 558 AA 

Protein Sequence

Gene Ontology

 GO:0004044; F:amidophosphoribosyltransferase activity; IEA:EC.
 GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0035690; P:cellular response to drug; IEA:Compara.
 GO:0032869; P:cellular response to insulin stimulus; IEA:Compara.
 GO:0000082; P:G1/S transition of mitotic cell cycle; IEA:Compara.
 GO:0006543; P:glutamine catabolic process; IEA:Compara.
 GO:0001822; P:kidney development; IEA:Compara.
 GO:0007595; P:lactation; IEA:Compara.
 GO:0060135; P:maternal process involved in female pregnancy; IEA:Compara.
 GO:0009116; P:nucleoside metabolic process; IEA:InterPro.
 GO:0031100; P:organ regeneration; IEA:Compara.
 GO:0051289; P:protein homotetramerization; IEA:Compara.
 GO:0009113; P:purine nucleobase biosynthetic process; IEA:InterPro. 

Interpro

 IPR005854; Amd_phspho_trans.
 IPR017932; GATase_2_dom.
 IPR000583; GATase_dom.
 IPR000836; PRibTrfase_dom. 

Pfam

 PF00310; GATase_2
 PF00156; Pribosyltran 

SMART

  

PROSITE

 PS51278; GATASE_TYPE_2 

PRINTS