| Tag | Content |
|---|
| CPLM ID | CPLM-014574 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Alpha-aminoadipic semialdehyde dehydrogenase |
Protein Synonyms/Alias | Alpha-AASA dehydrogenase; Aldehyde dehydrogenase family 7 member A1; Antiquitin-1; Betaine aldehyde dehydrogenase; Delta1-piperideine-6-carboxylate dehydrogenase; P6c dehydrogenase |
Gene Name | Aldh7a1 |
Gene Synonyms/Alias | Ald7a1 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 86 | RVRQASMKDYEETIG | acetylation | [1] | | 94 | DYEETIGKAKKAWNI | acetylation | [1] | | 97 | ETIGKAKKAWNIWAD | acetylation | [1] | | 109 | WADIPAPKRGEIVRK | acetylation | [1] | | 124 | IGDALREKIQLLGRL | acetylation | [1] | | 351 | DEVVDRLKNAYSQIR | acetylation | [1] | | 375 | LYGPLHTKQAVSMFV | acetylation | [1] | | 389 | VQAVEEAKKEGGTVV | acetylation | [1] | | 390 | QAVEEAKKEGGTVVY | acetylation | [1] | | 400 | GTVVYGGKVMDHPGN | acetylation | [1] | | 426 | HDAPIVHKETFAPIL | acetylation | [1] | | 439 | ILYVFKFKNEEEVFE | acetylation | [1] | | 452 | FEWNNEVKQGLSSSI | acetylation | [1] | | 462 | LSSSIFTKDLGRIFR | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism (By similarity). |
Sequence Annotation | NP_BIND 274 279 NAD (By similarity).
ACT_SITE 296 296 Proton acceptor (By similarity).
ACT_SITE 330 330 Nucleophile (By similarity). |
Keyword | Complete proteome; Cytoplasm; Direct protein sequencing; Mitochondrion; NAD; Nucleus; Oxidoreductase; Reference proteome; Transit peptide. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 539 AA |
Protein Sequence | MLRLARPLCV QTVKASKLSR LWSRPAALMS TLLIHHPQYA WLQDLGLRED NEGVFNGSWG 60
GRGEVITTYC PANNEPIARV RQASMKDYEE TIGKAKKAWN IWADIPAPKR GEIVRKIGDA 120
LREKIQLLGR LVSLEMGKIL VEGIGEVQEY VDVCDYAAGL SRMIGGPTLP SERPGHALME 180
QWNPLGLVGI ITAFNFPVAV FGWNNAIALI TGNVCLWKGA PTTSLVSIAV TKIIAKVLED 240
NLLPGAICSL TCGGADMGTA MARDERVNLL SFTGSTQVGK QVALMVQERF GKSLLELGGN 300
NAIIAFEDAD LSLVLPSALF AAVGTAGQRC TTVRRLFLHE SIHDEVVDRL KNAYSQIRVG 360
NPWDPNILYG PLHTKQAVSM FVQAVEEAKK EGGTVVYGGK VMDHPGNYVE PTIVTGLVHD 420
APIVHKETFA PILYVFKFKN EEEVFEWNNE VKQGLSSSIF TKDLGRIFRW LGPKGSDCGI 480
VNVNIPTSGA EIGGAFGGEK HTGGGRESGS DAWKQYMRRS TCTINYSTAL PLAQGIKFQ 539 |
Gene Ontology | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell. GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0008802; F:betaine-aldehyde dehydrogenase activity; IEA:EC. GO:0004043; F:L-aminoadipate-semialdehyde dehydrogenase activity; IEA:EC. GO:0019285; P:glycine betaine biosynthetic process from choline; IEA:UniProtKB-UniPathway. |
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Pfam | |
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