CPLM-009587

Genbank Nucleotide ID

40S ribosomal protein S24

Protein Synonyms/Alias

Mus musculus (Mouse)

Position	Peptide	Type	References
21	TNRLLQRKQMVIDVL	ubiquitination	[1]
37	PGKATVPKTEIREKL	acetylation	[2, 3, 4]
37	PGKATVPKTEIREKL	ubiquitination	[1]
68	RTHFGGGKTTGFGMI	acetylation	[5]
83	YDSLDYAKKNEPKHR	acetylation	[4, 5, 6]
83	YDSLDYAKKNEPKHR	ubiquitination	[1, 7]
84	DSLDYAKKNEPKHRL	ubiquitination	[7]
88	YAKKNEPKHRLARHG	ubiquitination	[7]
122	KKVRGTAKANVGAGK	acetylation	[8]
122	KKVRGTAKANVGAGK	succinylation	[8]

[1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
[2] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
Simon GM, Cheng J, Gordon JI.
Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
[3] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
[4] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
[5] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
PLoS One. 2012;7(12):e50545. [PMID: 23236377]
[6] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
[7] BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs.
Mathew R, Seiler MP, Scanlon ST, Mao AP, Constantinides MG, Bertozzi-Villa C, Singer JD, Bendelac A.
Nature. 2012 Nov 22;491(7425):618-21. [PMID: 23086144]
[8] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]

Functional Description

Required for processing of pre-rRNA and maturation of 40S ribosomal subunits (By similarity).

MOD_RES 1 1 N-acetylmethionine (By similarity).
MOD_RES 9 9 Phosphothreonine (By similarity).
MOD_RES 81 81 Phosphotyrosine.

Acetylation; Alternative splicing; Complete proteome; Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosomal protein.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0022627; C:cytosolic small ribosomal subunit; ISO:MGI.
GO:0005730; C:nucleolus; IBA:RefGenome.
GO:0000166; F:nucleotide binding; IEA:InterPro.
GO:0003735; F:structural constituent of ribosome; ISO:MGI.
GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:RefGenome.
GO:0006414; P:translational elongation; IBA:RefGenome.

IPR012677; Nucleotide-bd_a/b_plait.
IPR012678; Ribosomal_L23/L15e_core_dom.
IPR001976; Ribosomal_S24e.
IPR018098; Ribosomal_S24e_CS.

PF01282; Ribosomal_S24e

PS00529; RIBOSOMAL_S24E