| Tag | Content |
|---|
| CPLM ID | CPLM-005384 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Cysteine desulfurase, mitochondrial |
Protein Synonyms/Alias | tRNA-splicing protein SPL1 |
Gene Name | NFS1 |
Gene Synonyms/Alias | SPL1; YCL017C; YCL17C |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 160 | KMINADPKEIIFTSG | acetylation | [1] | | 464 | EEVDYVVKAVSDRVK | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron- sulfur (Fe-S) clusters. Involved in both tRNA-processing and mitochondrial metabolism. |
Sequence Annotation | ACT_SITE 421 421 By similarity.
MOD_RES 299 299 N6-(pyridoxal phosphate)lysine (By |
Keyword | Complete proteome; Mitochondrion; Pyridoxal phosphate; Reference proteome; Transferase; Transit peptide; tRNA processing. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 497 AA |
Protein Sequence | MLKSTATRSI TRLSQVYNVP AATYRACLVS RRFYSPPAAG VKLDDNFSLE THTDIQAAAK 60
AQASARASAS GTTPDAVVAS GSTAMSHAYQ ENTGFGTRPI YLDMQATTPT DPRVLDTMLK 120
FYTGLYGNPH SNTHSYGWET NTAVENARAH VAKMINADPK EIIFTSGATE SNNMVLKGVP 180
RFYKKTKKHI ITTRTEHKCV LEAARAMMKE GFEVTFLNVD DQGLIDLKEL EDAIRPDTCL 240
VSVMAVNNEI GVIQPIKEIG AICRKNKIYF HTDAAQAYGK IHIDVNEMNI DLLSISSHKI 300
YGPKGIGAIY VRRRPRVRLE PLLSGGGQER GLRSGTLAPP LVAGFGEAAR LMKKEFDNDQ 360
AHIKRLSDKL VKGLLSAEHT TLNGSPDHRY PGCVNVSFAY VEGESLLMAL RDIALSSGSA 420
CTSASLEPSY VLHALGKDDA LAHSSIRFGI GRFSTEEEVD YVVKAVSDRV KFLRELSPLW 480
EMVQEGIDLN SIKWSGH 497 |
Gene Ontology | GO:0005739; C:mitochondrion; IDA:SGD. GO:0005634; C:nucleus; IDA:SGD. GO:0031071; F:cysteine desulfurase activity; IDA:SGD. GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. GO:0006879; P:cellular iron ion homeostasis; IMP:SGD. GO:0006534; P:cysteine metabolic process; IEA:InterPro. GO:0016226; P:iron-sulfur cluster assembly; IDA:SGD. GO:0070903; P:mitochondrial tRNA thio-modification; IMP:SGD. GO:0002098; P:tRNA wobble uridine modification; IMP:SGD. |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |