UniProt Accession

 ANM1_HUMAN; Q99873; B4E3C3; G5E9B6; Q15529; Q2VP93; Q6LEU5; Q8WUW5; Q99872; Q99874; Q9NZ04; Q9NZ05; Q9NZ06 

Genbank Protein ID

 Y10805; Y10806; Y10807; D66904; AF222689; AF222689; AF222689; AK304660; CR407608; AC011495; CH471177; BC019268; BC109282; BC109283 

Genbank Nucleotide ID

 CAA71763.1; CAA71764.1; CAA71765.1; BAA11029.1; AAF62893.1; AAF62894.1; AAF62895.1; BAG65435.1; CAG28536.1; EAW52521.1; AAH19268.2; AAI09283.2; AAI09284.2 

Protein Name

 Protein arginine N-methyltransferase 1 

Protein Synonyms/Alias

 Histone-arginine N-methyltransferase PRMT1; Interferon receptor 1-bound protein 4 

Gene Name

 PRMT1 

Gene Synonyms/Alias

 HMT2; HRMT1L2; IR1B4 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
107	DYAVKIVKANKLDHV	ubiquitination	[1]
110	VKIVKANKLDHVVTI	ubiquitination	[1]
159	TVLYARDKWLAPDGL	ubiquitination	[1]
209	CIKDVAIKEPLVDVV	ubiquitination	[1]
289	ESPYTHWKQTVFYME	ubiquitination	[1]
318	IGMRPNAKNNRDLDF	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates FOXO1 and retains it in the nucleus increasing its transcriptional acivity. 

Sequence Annotation

 ACT_SITE 152 152 By similarity.
 ACT_SITE 161 161 By similarity.
 BINDING 53 53 S-adenosyl-L-methionine (By similarity).
 BINDING 62 62 S-adenosyl-L-methionine (By similarity).
 BINDING 86 86 S-adenosyl-L-methionine; via carbonyl
 BINDING 108 108 S-adenosyl-L-methionine (By similarity).
 BINDING 137 137 S-adenosyl-L-methionine (By similarity).  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Methyltransferase; Nucleus; Polymorphism; Reference proteome; S-adenosyl-L-methionine; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 361 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; TAS:ProtInc.
 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0016275; F:[cytochrome c]-arginine N-methyltransferase activity; IEA:Compara.
 GO:0044020; F:histone methyltransferase activity (H4-R3 specific); IDA:UniProtKB.
 GO:0035242; F:protein-arginine omega-N asymmetric methyltransferase activity; IEA:Compara.
 GO:0035241; F:protein-arginine omega-N monomethyltransferase activity; IEA:Compara.
 GO:0030519; F:snoRNP binding; IEA:Compara.
 GO:0007166; P:cell surface receptor signaling pathway; TAS:ProtInc.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0045653; P:negative regulation of megakaryocyte differentiation; IDA:UniProtKB.
 GO:0031175; P:neuron projection development; IMP:UniProtKB. 

Interpro

 IPR025799; Arg_MeTrfase.
 IPR025714; Methyltranfer_dom. 

Pfam

 PF13847; Methyltransf_31 

SMART

  

PROSITE

  

PRINTS