| Tag | Content |
|---|
| CPLM ID | CPLM-021744 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Electrogenic sodium bicarbonate cotransporter 1 |
Protein Synonyms/Alias | Sodium bicarbonate cotransporter; NBC-like protein; Na(+)/HCO3(-) cotransporter; Solute carrier family 4 member 4 |
Gene Name | Slc4a4 |
Gene Synonyms/Alias | Nbc; Nbc1; Nbce1; Rnbc1 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 203 | LKPDLKDKVTYTLLR | ubiquitination | [1] | | 229 | RSLADIGKTVSSASR | ubiquitination | [1] | | 1067 | SPPRSPVKVVPQIRI | ubiquitination | [1] |
|
Reference | [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. |
Sequence Annotation | REGION 748 779 Interaction with CA4 (By similarity).
REGION 1002 1004 CA2-binding (By similarity).
REGION 1030 1033 CA2-binding (By similarity).
REGION 1057 1059 Required for basolateral targeting (By
MOD_RES 30 30 Phosphotyrosine (By similarity).
MOD_RES 254 254 Phosphothreonine (By similarity).
MOD_RES 255 255 Phosphoserine (By similarity).
MOD_RES 257 257 Phosphoserine (By similarity).
MOD_RES 262 262 Phosphoserine (By similarity).
MOD_RES 1026 1026 Phosphoserine; by PKA (By similarity).
MOD_RES 1029 1029 Phosphoserine (By similarity).
MOD_RES 1034 1034 Phosphoserine (By similarity).
CARBOHYD 641 641 N-linked (GlcNAc...).
CARBOHYD 661 661 N-linked (GlcNAc...). |
Keyword | Alternative splicing; Cell membrane; Complete proteome; Glycoprotein; Ion transport; Membrane; Phosphoprotein; Reference proteome; Sodium; Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1079 AA |
Protein Sequence | MEDEAVLDRG ASFLKHVCDE EEVEGHHTIY IGVHVPKSYR RRRRHKRKAG HKEKKEKERI 60
SENYSDKSDV ENADESSSSI LKPLISPAAE RIRFILGEED DSPAPPQLFT ELDELLAVDG 120
QEMEWKETAR WIKFEEKVEQ GGERWSKPHV ATLSLHSLFE LRTCMEKGSI MLDREASSLP 180
QLVEMIADHQ IETGLLKPDL KDKVTYTLLR KHRHQTKKSN LRSLADIGKT VSSASRMFSN 240
PDNGSPAMTH RNLTSSSLND ISDKPEKDQL KNKFMKKLPR DAEASNVLVG EVDFLDTPFI 300
AFVRLQQAVM LGALTEVPVP TRFLFILLGP KGKAKSYHEI GRAIATLMSD EVFHDIAYKA 360
KDRHDLIAGI DEFLDEVIVL PPGEWDPAIR IEPPKSLPSS DKRKNMYSGG ENVQMNGDTP 420
HDGGHGGGGH GDCEELQRTG RFCGGLIKDI KRKAPFFASD FYDALNIQAL SAILFIYLAT 480
VTNAITFGGL LGDATDNMQG VLESFLGTAV SGAIFCLFAG QPLTILSSTG PVLVFERLLF 540
NFSKDHSFDY LEFRLWIGLW SAFMCLILVA TDASFLVQYF TRFTEEGFSS LISFIFIYDA 600
FKKMIKLADY YPINSDFRVG YNTHFSCACL PPDPVNLSVS NDTTLAPEDL PTVSSTDMYH 660
NATFDWAYLS KKECVKFGGK LVGNNCDFVP DITLMSFILF LGTYTSSMAM KKFKTSRYFP 720
TTARKLISDF AIILSILIFC VIDALVGVDT PKLIVPSEFK PTSPHRGWFV PPFGGNPWWV 780
CLAAAIPALL VTILIFMDQQ ITAVIVNRKE HKLKKGAGYH LDLFWVAILM VVCSFMALPW 840
YVAATVISIA HIDSLKMETE TSAPGEQPKF LGVREQRVTG TLVFILTGLS VFMAPILKFI 900
PMPVLYGVFL YMGVASLNGV QFMDRLKLLL MPLKHQPDFI YLRHVPLRRV HLFTSLQVLC 960
LALLWILKST VAAIIFPVMI LALVAVRKGM DYLFSQHDLS FLDDVIPEKD KKKKEDEKKK 1020
KKKKGSLDSD NDDEKDPQHS LNATHHADKI PFLESLGLPS PPRSPVKVVP QIRIELESED 1080
NDYLWRNKGT ETTL 1094 |
Gene Ontology | GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell. GO:0005887; C:integral to plasma membrane; TAS:RGD. GO:0005452; F:inorganic anion exchanger activity; IEA:InterPro. GO:0008510; F:sodium:bicarbonate symporter activity; TAS:RGD. GO:0006885; P:regulation of pH; TAS:RGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |