UniProt Accession

 COR1A_RAT; Q91ZN1 

Genbank Protein ID

 AF416730; AF495469; BC086971 

Genbank Nucleotide ID

 AAL18695.1; AAM18515.1; AAH86971.1 

Protein Name

 Coronin-1A 

Protein Synonyms/Alias

 Coronin-like protein A; Clipin-A; Tryptophan aspartate-containing coat protein; TACO 

Gene Name

 Coro1a 

Gene Synonyms/Alias

 Coro1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
446	NLNAIVQKLQERLDR	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion (By similarity). 

Sequence Annotation

 REPEAT 13 63 WD 1.
 REPEAT 73 110 WD 2.
 REPEAT 123 160 WD 3.
 REPEAT 164 204 WD 4.
 REPEAT 207 251 WD 5.
 REPEAT 258 296 WD 6.
 REPEAT 302 349 WD 7.
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 2 2 Phosphoserine; by PKC (By similarity).
 MOD_RES 412 412 Phosphoserine; by PKC (By similarity).
 MOD_RES 418 418 Phosphothreonine (By similarity).  

Keyword

 Acetylation; Actin-binding; Coiled coil; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Cytoskeleton; Direct protein sequencing; Membrane; Phosphoprotein; Reference proteome; Repeat; WD repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 461 AA 

Protein Sequence

Gene Ontology

 GO:0005884; C:actin filament; IEA:Compara.
 GO:0030864; C:cortical actin cytoskeleton; IBA:RefGenome.
 GO:0001772; C:immunological synapse; IEA:Compara.
 GO:0030027; C:lamellipodium; IBA:RefGenome.
 GO:0001891; C:phagocytic cup; IBA:RefGenome.
 GO:0045335; C:phagocytic vesicle; IBA:RefGenome.
 GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0051015; F:actin filament binding; IBA:RefGenome.
 GO:0007015; P:actin filament organization; IEA:Compara.
 GO:0006816; P:calcium ion transport; IEA:Compara.
 GO:0031589; P:cell-substrate adhesion; IEA:Compara.
 GO:0048873; P:homeostasis of number of cells within a tissue; IEA:Compara.
 GO:0030595; P:leukocyte chemotaxis; IBA:RefGenome.
 GO:0051126; P:negative regulation of actin nucleation; IBA:RefGenome.
 GO:0001845; P:phagolysosome assembly; IBA:RefGenome.
 GO:0050918; P:positive chemotaxis; IBA:RefGenome.
 GO:0030335; P:positive regulation of cell migration; IEA:Compara.
 GO:0042102; P:positive regulation of T cell proliferation; IEA:Compara.
 GO:0030833; P:regulation of actin filament polymerization; IEA:Compara.
 GO:0008360; P:regulation of cell shape; IBA:RefGenome.
 GO:0034097; P:response to cytokine stimulus; IEA:Compara.
 GO:0030217; P:T cell differentiation; NAS:RGD.
 GO:0043029; P:T cell homeostasis; IEA:Compara.
 GO:0032796; P:uropod organization; IBA:RefGenome. 

Interpro

 IPR027334; CORO1A.
 IPR015505; Coronin.
 IPR015048; DUF1899.
 IPR015049; DUF1900.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 

Pfam

 PF08953; DUF1899
 PF08954; DUF1900
 PF00400; WD40 

SMART

 SM00320; WD40 

PROSITE

 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 

PRINTS