CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005317
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Lysosomal acid phosphatase 
Protein Synonyms/Alias
 LAP 
Gene Name
 Acp2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
153ITEDRLLKFPLGPCPubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
 ACT_SITE 42 42 Nucleophile (By similarity).
 ACT_SITE 287 287 Proton donor (By similarity).
 CARBOHYD 92 92 N-linked (GlcNAc...) (Potential).
 CARBOHYD 133 133 N-linked (GlcNAc...) (Potential).
 CARBOHYD 167 167 N-linked (GlcNAc...) (Potential).
 CARBOHYD 177 177 N-linked (GlcNAc...) (Potential).
 CARBOHYD 191 191 N-linked (GlcNAc...) (Potential).
 CARBOHYD 197 197 N-linked (GlcNAc...) (Potential).
 CARBOHYD 267 267 N-linked (GlcNAc...) (Potential).
 CARBOHYD 322 322 N-linked (GlcNAc...) (Potential).
 CARBOHYD 331 331 N-linked (GlcNAc...) (Potential).
 CARBOHYD 374 374 N-linked (GlcNAc...) (Potential).
 DISULFID 159 370 By similarity.
 DISULFID 212 310 By similarity.
 DISULFID 345 349 By similarity.  
Keyword
 Complete proteome; Disulfide bond; Glycoprotein; Hydrolase; Lysosome; Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 423 AA 
Protein Sequence
MAGRQTGWSQ AALLQFLLGM CLTVMPPIQA RSLRFVTLLY RHGDRSPVKT YPKDPYQEEK 60
WPQGFGQLTK EGMLQHWELG QALRQRYHGF LNTSYHRQEV YVRSTDFDRT LMSAEANLAG 120
LFPPNEVQHF NPNISWQPIP VHTVPITEDR LLKFPLGPCP RYEQLQNETR QTPEYQNRSI 180
QNAQFLNMVA NETGLTNVTL ETIWNVYDTL FCEQTHGLLL PPWASPQTVQ RLSQLKDFSF 240
LFLFGIHEQV QKARLQGGVL LAQILKNLTL MATTSQFPKL LVYSAHDTTL VALQMALNVY 300
NGKQAPYASC HIFELYQEDN GNFSVEMYFR NDSKKAPWPL ILPGCPHRCP LQDFLRLTEP 360
VIPKDWQKEC QLANDTADTE VIVALAVCGS ILFLLIVLLL TILFRMQAQP PGYHHVADRE 420
DHA 423 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0043202; C:lysosomal lumen; IEA:UniProtKB-SubCell.
 GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
 GO:0005764; C:lysosome; IDA:MGI.
 GO:0003993; F:acid phosphatase activity; IDA:MGI.
 GO:0007040; P:lysosome organization; IMP:MGI.
 GO:0001501; P:skeletal system development; IMP:MGI. 
Interpro
 IPR000560; His_Pase_superF_clade-2. 
Pfam
 PF00328; His_Phos_2 
SMART
  
PROSITE
 PS00616; HIS_ACID_PHOSPHAT_1
 PS00778; HIS_ACID_PHOSPHAT_2 
PRINTS