UniProt Accession

 PDP2_HUMAN; Q9P2J9; A8K924 

Genbank Protein ID

 AB037769; AK292539; CH471092; BC028030 

Genbank Nucleotide ID

 BAA92586.1; BAF85228.1; EAW83048.1; AAH28030.1 

Protein Name

 [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial 

Protein Synonyms/Alias

 PDP 2; Pyruvate dehydrogenase phosphatase catalytic subunit 2; PDPC 2 

Gene Name

 PDP2 

Gene Synonyms/Alias

 KIAA1348 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
94	RAGETTHKILDLESR	ubiquitination	[1]
357	DVQLKWSKELQRSIL	ubiquitination	[1]
438	LAEADWHKTDLAQRP	ubiquitination	[2, 3]
459	QSLLLQRKASGLHEA	ubiquitination	[1, 4]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] A data set of human endogenous protein ubiquitination sites.
 Shi Y, Chan DW, Jung SY, Malovannaya A, Wang Y, Qin J.
 Mol Cell Proteomics. 2011 May;10(5):M110.002089. [PMID: 20972266] 

Functional Description

 Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (By similarity). 

Sequence Annotation

 METAL 141 141 Manganese 1 (By similarity).
 METAL 141 141 Manganese 2 (By similarity).
 METAL 142 142 Manganese 1; via carbonyl oxygen (By
 METAL 412 412 Manganese 2 (By similarity).  

Keyword

 Complete proteome; Hydrolase; Magnesium; Manganese; Metal-binding; Mitochondrion; Protein phosphatase; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 529 AA 

Protein Sequence

Gene Ontology

 GO:0005759; C:mitochondrial matrix; TAS:Reactome.
 GO:0004741; F:[pyruvate dehydrogenase (lipoamide)] phosphatase activity; IEA:EC.
 GO:0004724; F:magnesium-dependent protein serine/threonine phosphatase activity; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0035970; P:peptidyl-threonine dephosphorylation; IEA:Compara.
 GO:0006090; P:pyruvate metabolic process; TAS:Reactome.
 GO:0010510; P:regulation of acetyl-CoA biosynthetic process from pyruvate; TAS:Reactome. 

Interpro

 IPR001932; PP2C-like.
 IPR000222; PP2C_Mn2_Asp60_BS.
 IPR015655; Protein_Pase_2C. 

Pfam

 PF00481; PP2C 

SMART

 SM00331; PP2C_SIG
 SM00332; PP2Cc 

PROSITE

 PS01032; PP2C 

PRINTS