CPLM-004008

Genbank Nucleotide ID

ADP/ATP translocase 1

Protein Synonyms/Alias

ADP,ATP carrier protein 1; ADP,ATP carrier protein, heart/skeletal muscle isoform T1; Adenine nucleotide translocator 1; ANT 1; Solute carrier family 25 member 4

Homo sapiens (Human)

Position	Peptide	Type	References
23	GVAAAVSKTAVAPIE	acetylation	[1]
43	LQVQHASKQISAEKQ	ubiquitination	[2, 3, 4, 5]
63	DCVVRIPKEQGFLSF	ubiquitination	[2, 5]
96	FAFKDKYKQLFLGGV	acetylation	[1, 6]
96	FAFKDKYKQLFLGGV	ubiquitination	[2, 5]
107	LGGVDRHKQFWRYFA	ubiquitination	[7]
147	RLAADVGKGAAQREF	ubiquitination	[3, 7]
199	FGVYDTAKGMLPDPK	ubiquitination	[2, 3]
245	MMMQSGRKGADIMYT	ubiquitination	[2]
272	EGAKAFFKGAWSNVL	ubiquitination	[4, 7]

[1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
PLoS One. 2012;7(12):e50545. [PMID: 23236377]
[2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
[3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
[4] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
[5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
Chen Z, Zhou Y, Song J, Zhang Z.
Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
[6] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
[7] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]

Functional Description

Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane.

REPEAT 6 98 Solcar 1.
REPEAT 111 201 Solcar 2.
REPEAT 212 297 Solcar 3.
MOTIF 235 240 Substrate recognition (By similarity).
BINDING 80 80 Nucleotide (By similarity).
MOD_RES 2 2 N-acetylglycine.
CROSSLNK 10 10 Glycyl lysine isopeptide (Lys-Gly)

Acetylation; Complete proteome; Direct protein sequencing; Disease mutation; Host-virus interaction; Isopeptide bond; Membrane; Mitochondrion; Mitochondrion inner membrane; Progressive external ophthalmoplegia; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport; Ubl conjugation.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
GO:0015207; F:adenine transmembrane transporter activity; TAS:ProtInc.
GO:0008637; P:apoptotic mitochondrial changes; IEA:Compara.
GO:0006112; P:energy reserve metabolic process; TAS:Reactome.
GO:0000002; P:mitochondrial genome maintenance; TAS:ProtInc.
GO:0060547; P:negative regulation of necrotic cell death; IMP:BHF-UCL.
GO:0050796; P:regulation of insulin secretion; TAS:Reactome.
GO:0044281; P:small molecule metabolic process; TAS:Reactome.
GO:0016032; P:viral reproduction; TAS:Reactome.
GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW.

IPR002113; Aden_trnslctor.
IPR002067; Mit_carrier.
IPR018108; Mitochondrial_sb/sol_carrier.
IPR023395; Mt_carrier_dom.

PR00927; ADPTRNSLCASE.
PR00926; MITOCARRIER.