CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018774
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Unconventional myosin-XVIIIa 
Protein Synonyms/Alias
 Molecule associated with JAK3 N-terminus; MAJN; Myosin containing a PDZ domain 
Gene Name
 MYO18A 
Gene Synonyms/Alias
 KIAA0216; MYSPDZ 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
377ELNLPEGKVRVKLDHubiquitination[1]
457APAVYSEKVMHMFKGubiquitination[1]
644KAAQQFSKLQAAMKVubiquitination[1]
1038ALIDTIKKSKLHFVHubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). In concert with LURAP1 and CDC42BPA/CDC42BPB, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. 
Sequence Annotation
 DOMAIN 220 311 PDZ.
 DOMAIN 420 1186 Myosin head-like.
 DOMAIN 1188 1217 IQ.
 NP_BIND 498 505 ATP (Potential).
 MOTIF 114 118 Interaction with actin.
 MOD_RES 72 72 Phosphoserine (By similarity).
 MOD_RES 74 74 Phosphoserine (By similarity).
 MOD_RES 83 83 Phosphoserine.
 MOD_RES 102 102 Phosphoserine (By similarity).
 MOD_RES 140 140 Phosphoserine.
 MOD_RES 164 164 Phosphoserine (By similarity).
 MOD_RES 1070 1070 Phosphoserine.
 MOD_RES 1970 1970 Phosphoserine.
 MOD_RES 1974 1974 Phosphoserine.
 MOD_RES 1998 1998 Phosphoserine.
 MOD_RES 2002 2002 Phosphoserine.
 MOD_RES 2007 2007 Phosphoserine.
 MOD_RES 2020 2020 Phosphoserine.
 MOD_RES 2036 2036 Phosphoserine (By similarity).
 MOD_RES 2041 2041 Phosphoserine.
 MOD_RES 2043 2043 Phosphoserine.
 MOD_RES 2045 2045 Phosphothreonine.  
Keyword
 Alternative splicing; ATP-binding; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Motor protein; Myosin; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2054 AA 
Protein Sequence
MFNLMKKDKD KDGGRKEKKE KKEKKERMSA AELRSLEEMS LRRGFFNLNR SSKRESKTRL 60
EISNPIPIKV ASGSDLHLTD IDSDSNRGSV ILDSGHLSTA SSSDDLKGEE GSFRGSVLQR 120
AAKFGSLAKQ NSQMIVKRFS FSQRSRDESA SETSTPSEHS AAPSPQVEVR TLEGQLVQHP 180
GPGIPRPGHR SRAPELVTKK FPVDLRLPPV VPLPPPTLRE LELQRRPTGD FGFSLRRTTM 240
LDRGPEGQAC RRVVHFAEPG AGTKDLALGL VPGDRLVEIN GHNVESKSRD EIVEMIRQSG 300
DSVRLKVQPI PELSELSRSW LRSGEGPRRE PSDAKTEEQI AAEEAWNETE KVWLVHRDGF 360
SLASQLKSEE LNLPEGKVRV KLDHDGAILD VDEDDVEKAN APSCDRLEDL ASLVYLNESS 420
VLHTLRQRYG ASLLHTYAGP SLLVLGPRGA PAVYSEKVMH MFKGCRREDM APHIYAVAQT 480
AYRAMLMSRQ DQSIILLGSS GSGKTTSCQH LVQYLATIAG ISGNKVFSVE KWQALYTLLE 540
AFGNSPTIIN GNATRFSQIL SLDFDQAGQV ASASIQTMLL EKLRVARRPA SEATFNVFYY 600
LLACGDGTLR TELHLNHLAE NNVFGIVPLA KPEEKQKAAQ QFSKLQAAMK VLGISPDEQK 660
ACWFILAAIY HLGAAGATKE AAEAGRKQFA RHEWAQKAAY LLGCSLEELS SAIFKHQHKG 720
GTLQRSTSFR QGPEESGLGD GTGPKLSALE CLEGMAAGLY SELFTLLVSL VNRALKSSQH 780
SLCSMMIVDT PGFQNPEQGG SARGASFEEL CHNYTQDRLQ RLFHERTFVQ ELERYKEENI 840
ELAFDDLEPP TDDSVAAVDQ ASHQSLVRSL ARTDEARGLL WLLEEEALVP GASEDTLLER 900
LFSYYGPQEG DKKGQSPLLH SSKPHHFLLG HSHGTNWVEY NVTGWLNYTK QNPATQNAPR 960
LLQDSQKKII SNLFLGRAGS ATVLSGSIAG LEGGSQLALR RATSMRKTFT TGMAAVKKKS 1020
LCIQMKLQVD ALIDTIKKSK LHFVHCFLPV AEGWAGEPRS ASSRRVSSSS ELDLPSGDHC 1080
EAGLLQLDVP LLRTQLRGSR LLDAMRMYRQ GYPDHMVFSE FRRRFDVLAP HLTKKHGRNY 1140
IVVDERRAVE ELLECLDLEK SSCCMGLSRV FFRAGTLARL EEQRDEQTSR NLTLFQAACR 1200
GYLARQHFKK RKIQDLAIRC VQKNIKKNKG VKDWPWWKLF TTVRPLIEVQ LSEEQIRNKD 1260
EEIQQLRSKL EKAEKERNEL RLNSDRLESR ISELTSELTD ERNTGESASQ LLDAETAERL 1320
RAEKEMKELQ TQYDALKKQM EVMEMEVMEA RLIRAAEING EVDDDDAGGE WRLKYERAVR 1380
EVDFTKKRLQ QEFEDKLEVE QQNKRQLERR LGDLQADSEE SQRALQQLKK KCQRLTAELQ 1440
DTKLHLEGQQ VRNHELEKKQ RRFDSELSQA HEEAQREKLQ REKLQREKDM LLAEAFSLKQ 1500
QLEEKDMDIA GFTQKVVSLE AELQDISSQE SKDEASLAKV KKQLRDLEAK VKDQEEELDE 1560
QAGTIQMLEQ AKLRLEMEME RMRQTHSKEM ESRDEEVEEA RQSCQKKLKQ MEVQLEEEYE 1620
DKQKVLREKR ELEGKLATLS DQVNRRDFES EKRLRKDLKR TKALLADAQL MLDHLKNSAP 1680
SKREIAQLKN QLEESEFTCA AAVKARKAME VEIEDLHLQI DDIAKAKTAL EEQLSRLQRE 1740
KNEIQNRLEE DQEDMNELMK KHKAAVAQAS RDLAQINDLQ AQLEEANKEK QELQEKLQAL 1800
QSQVEFLEQS MVDKSLVSRQ EAKIRELETR LEFERTQVKR LESLASRLKE NMEKLTEERD 1860
QRIAAENREK EQNKRLQRQL RDTKEEMGEL ARKEAEASRK KHELEMDLES LEAANQSLQA 1920
DLKLAFKRIG DLQAAIEDEM ESDENEDLIN SLQDMVTKYQ KRKNKLEGDS DVDSELEDRV 1980
DGVKSWLSKN KGPSKAASDD GSLKSSSPTS YWKSLAPDRS DDEHDPLDNT SRPRYSHSYL 2040
SDSDTEAKLT ETNA 2054 
Gene Ontology
 GO:0042641; C:actomyosin; IDA:UniProtKB.
 GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell.
 GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0008094; F:DNA-dependent ATPase activity; IEA:InterPro.
 GO:0003774; F:motor activity; IEA:InterPro.
 GO:0031032; P:actomyosin structure organization; IMP:UniProtKB.
 GO:0016477; P:cell migration; IMP:UniProtKB.
 GO:0006259; P:DNA metabolic process; IEA:InterPro.
 GO:0043066; P:negative regulation of apoptotic process; TAS:ProtInc. 
Interpro
 IPR000048; IQ_motif_EF-hand-BS.
 IPR027401; Myosin-like_IQ_dom.
 IPR001609; Myosin_head_motor_dom.
 IPR002928; Myosin_tail.
 IPR027417; P-loop_NTPase.
 IPR001478; PDZ.
 IPR020587; RecA_monomer-monomer_interface. 
Pfam
 PF00063; Myosin_head
 PF01576; Myosin_tail_1
 PF00595; PDZ 
SMART
 SM00015; IQ
 SM00242; MYSc
 SM00228; PDZ 
PROSITE
 PS50096; IQ
 PS50106; PDZ 
PRINTS
 PR00193; MYOSINHEAVY.