UniProt Accession

 CDK1_DROME; P23572; A0ANT1; Q86FT5; Q86FT6; Q86FT7; Q86FT8; Q86FT9; Q9TX68; Q9TX69; Q9TX70; Q9TX71; Q9TX72; Q9TX73; Q9TX74; Q9VKX5 

Genbank Protein ID

 X57485; X57496; S66801; S66804; S66805; S66807; S66810; AM294319; AM294320; AM294321; AM294322; AM294323; AM294324; AM294325; AM294326; AM294327; AM294328; AM294329; AE014134; AY061450 

Genbank Nucleotide ID

 CAA40723.1; CAA40733.1; AAP13986.1; AAP13987.1; AAP13988.1; AAP13989.1; AAP13990.1; CAL26249.1; CAL26250.1; CAL26251.1; CAL26252.1; CAL26253.1; CAL26254.1; CAL26255.1; CAL26256.1; CAL26257.1; CAL26258.1; CAL26259.1; AAF52932.1; AAL28998.1 

Protein Name

 Cyclin-dependent kinase 1 

Protein Synonyms/Alias

 CDK1; Cell division control protein 2 homolog; Cell division protein kinase 1; p34 protein kinase 

Gene Name

 cdc2 

Gene Synonyms/Alias

 cdk1; CG5363 

Created Date

 July 27, 2013 

Organism

 Drosophila melanogaster (Fruit fly) 

NCBI Taxa ID

 7227 

Lysine Modification

Position	Peptide	Type	References
6	**MEDFEKIEKIGEG	acetylation	[1]

Reference

 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 

Functional Description

 Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II. 

Sequence Annotation

 DOMAIN 4 287 Protein kinase.
 NP_BIND 10 18 ATP (By similarity).
 ACT_SITE 128 128 Proton acceptor (By similarity).
 BINDING 33 33 ATP (By similarity).
 MOD_RES 14 14 Phosphothreonine.
 MOD_RES 15 15 Phosphotyrosine.
 MOD_RES 160 160 Phosphotyrosine.
 MOD_RES 161 161 Phosphothreonine; by CAK (Potential).  

Keyword

 ATP-binding; Cell cycle; Cell division; Complete proteome; Kinase; Mitosis; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 297 AA 

Protein Sequence

Gene Ontology

 GO:0005875; C:microtubule associated complex; IDA:FlyBase.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004693; F:cyclin-dependent protein serine/threonine kinase activity; ISS:FlyBase.
 GO:0008353; F:RNA polymerase II carboxy-terminal domain kinase activity; IEA:EC.
 GO:0055059; P:asymmetric neuroblast division; IMP:FlyBase.
 GO:0000082; P:G1/S transition of mitotic cell cycle; IGI:FlyBase.
 GO:0000086; P:G2/M transition of mitotic cell cycle; IMP:FlyBase.
 GO:0048142; P:germarium-derived cystoblast division; IMP:FlyBase.
 GO:0007141; P:male meiosis I; TAS:FlyBase.
 GO:0008315; P:meiotic G2/MI transition; TAS:FlyBase.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0032880; P:regulation of protein localization; IMP:FlyBase.
 GO:0006974; P:response to DNA damage stimulus; IMP:FlyBase.
 GO:0007284; P:spermatogonial cell division; IMP:FlyBase. 

Interpro

 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 

Pfam

 PF00069; Pkinase 

SMART

 SM00220; S_TKc 

PROSITE

 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 

PRINTS