CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018395
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glucose-6-phosphate isomerase 
Protein Synonyms/Alias
 GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI 
Gene Name
 pgi 
Gene Synonyms/Alias
 STM4221 
Created Date
 July 27, 2013 
Organism
 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 
NCBI Taxa ID
 99287 
Lysine Modification
Position
Peptide
Type
References
114TPIIVDGKDVMPEVNacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
  
Sequence Annotation
 ACT_SITE 355 355 Proton donor (By similarity).
 ACT_SITE 386 386 By similarity.
 ACT_SITE 514 514 By similarity.  
Keyword
 Complete proteome; Cytoplasm; Gluconeogenesis; Glycolysis; Isomerase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 549 AA 
Protein Sequence
MKNINPTQTS AWQALQKHYD EMKDVTIAEL FANDSDRFAK FSATFDDLML VDFSKNRITE 60
ETLAKLQDLA KETDLAGAIK SMFSGEKINR TEDRAVLHVA LRNRSNTPII VDGKDVMPEV 120
NAVLEKMKTF SQAIISGQWK GYTGKAITDV VNIGIGGSDL GPFMVTEALR PYKNHLTMHF 180
VSNVDGTHIA EVLKKVNPET TLFLVASKTF TTQETMTNAH SARDWFLKTA GDEKHVAKHF 240
AALSTNAKAV GEFGIDTANM FEFWDWVGGR YSLWSAIGLS IILSVGFDNF VELLSGAHAM 300
DKHFSTTPAE KNLPILLALI GIWYNNFFGA ETEAILPYDQ YMHRFAAYFQ QGNMESNGKY 360
VDRNGNAVDY QTGPIIWGEP GTNGQHAFYQ LIHQGTKMVP CDFIAPAITH NPLSDHHQKL 420
LSNFFAQTEA LAFGKSREVV EQEYRDQGKD PAQLEHVVPF KVFEGNRPTN SILLREITPF 480
SLGALIALYE HKIFTQGVIL NIFTFDQWGV ELGKQLANRI LPELGDDKAI SSHDSSTNGL 540
INRYKAWRA 549 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004347; F:glucose-6-phosphate isomerase activity; IEA:HAMAP.
 GO:0006094; P:gluconeogenesis; IEA:HAMAP.
 GO:0006096; P:glycolysis; IEA:HAMAP. 
Interpro
 IPR001672; G6P_Isomerase.
 IPR023096; G6P_Isomerase_C.
 IPR018189; Phosphoglucose_isomerase_CS. 
Pfam
 PF00342; PGI 
SMART
  
PROSITE
 PS00765; P_GLUCOSE_ISOMERASE_1
 PS00174; P_GLUCOSE_ISOMERASE_2
 PS51463; P_GLUCOSE_ISOMERASE_3 
PRINTS
 PR00662; G6PISOMERASE.