CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006189
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Fumarate reductase 
Protein Synonyms/Alias
 FAD-dependent oxidoreductase FRDS; NADH; NADH-dependent fumarate reductase 
Gene Name
 YEL047C; SYGP-ORF35 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
45SIGGNSIKASSGINGubiquitination[1]
303VVTAAIQKVCPQEDNubiquitination[1]
325EKMYTDLKNNLDFYMacetylation[2]
334NLDFYMFKKLVQKLTacetylation[2]
421VKAQVIGKNDERLLKacetylation[2]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 Could be a fumarate reductase. 
Sequence Annotation
 NP_BIND 6 20 AMP (Potential).
 ACT_SITE 249 249 By similarity.
 ACT_SITE 272 272 By similarity.
 MOD_RES 66 66 Phosphoserine.  
Keyword
 Complete proteome; Cytoplasm; Direct protein sequencing; FAD; Flavoprotein; Mitochondrion; NAD; Oxidoreductase; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 470 AA 
Protein Sequence
MSLSPVVVIG TGLAGLAAAN ELVNKYNIPV TILEKASSIG GNSIKASSGI NGACTETQRH 60
FHIEDSPRLF EDDTIKSAKG KGVQELMAKL ANDSPLAIEW LKNEFDLKLD LLAQLGGHSV 120
ARTHRSSGKL PPGFEIVSAL SNNLKKLAET KPELVKINLD SKVVDIHEKD GSISAVVYED 180
KNGEKHMVSA NDVVFCSGGF GFSKEMLKEY APELVNLPTT NGQQTTGDGQ RLLQKLGADL 240
IDMDQIQVHP TGFIDPNDRS SSWKFLAAES LRGLGGILLN PITGRRFVNE LTTRDVVTAA 300
IQKVCPQEDN RALLVMGEKM YTDLKNNLDF YMFKKLVQKL TLSQVVSEYN LPITVAQLCE 360
ELQTYSSFTT KADPLGRTVI LNEFGSDVTP ETVVFIGEVT PVVHFTMGGA RINVKAQVIG 420
KNDERLLKGL YAAGEVSGGV HGANRLGGSS LLECVVFGRT AAESIANDRK 470 
Gene Ontology
 GO:0005829; C:cytosol; IDA:SGD.
 GO:0005739; C:mitochondrion; IDA:SGD.
 GO:0005886; C:plasma membrane; IDA:SGD.
 GO:0016156; F:fumarate reductase (NADH) activity; IDA:SGD.
 GO:0000104; F:succinate dehydrogenase activity; IEA:InterPro.
 GO:0071454; P:cellular response to anoxia; IGI:SGD. 
Interpro
 IPR003953; FAD_bind_dom.
 IPR010960; Flavocytochrome_c.
 IPR027477; Succ_DH/fumarate_Rdtase_cat. 
Pfam
 PF00890; FAD_binding_2 
SMART
  
PROSITE
  
PRINTS