CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007031
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Kelch repeat-containing protein 1 
Protein Synonyms/Alias
  
Gene Name
 KEL1 
Gene Synonyms/Alias
 YHR158C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
40LSTPPNEKFFTKQETubiquitination[1]
44PNEKFFTKQETPQKGubiquitination[1]
758GDVPTDTKNEEASVPubiquitination[1]
985HHRVVINKLTNRLDDubiquitination[1]
1103EESSNNVKNSNSIREubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Has a role in cell morphogenesis and cell fusion and may antagonize the PKC1 pathway. 
Sequence Annotation
 REPEAT 139 186 Kelch 1.
 REPEAT 253 307 Kelch 2.
 REPEAT 308 357 Kelch 3.
 REPEAT 359 409 Kelch 4.
 REPEAT 411 460 Kelch 5.
 MOD_RES 20 20 Phosphoserine.
 MOD_RES 23 23 Phosphoserine.
 MOD_RES 25 25 Phosphoserine.
 MOD_RES 94 94 Phosphoserine.
 MOD_RES 467 467 Phosphothreonine.
 MOD_RES 477 477 Phosphothreonine.
 MOD_RES 503 503 Phosphoserine.
 MOD_RES 604 604 Phosphothreonine.
 MOD_RES 613 613 Phosphoserine.
 MOD_RES 626 626 Phosphothreonine.
 MOD_RES 689 689 Phosphoserine.
 MOD_RES 691 691 Phosphoserine.
 MOD_RES 717 717 Phosphoserine.
 MOD_RES 748 748 Phosphoserine.
 MOD_RES 837 837 Phosphoserine.
 MOD_RES 848 848 Phosphoserine.
 MOD_RES 958 958 Phosphoserine.
 MOD_RES 997 997 Phosphoserine.
 MOD_RES 1022 1022 Phosphoserine.  
Keyword
 Coiled coil; Complete proteome; Kelch repeat; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1164 AA 
Protein Sequence
MAGFSFAKKF THKKHGKTPS DASISDQSRE ASLSTPPNEK FFTKQETPQK GRQFSQGYHS 60
NVNKTSSPPM FARKQVSESR IQPSAVPPQQ RNVSGPSTTL HKQLSKQREY TVWNRIKLQN 120
SPFPRYRHVA SAYVTDKNQI YVIGGLHDQS VYGDTWILTA FDNATRFSTT TIDISEATPP 180
PRVGHAAVLC GNAFVVFGGD THKVNKEGLM DDDIYLLNIN SYKWTVPAPV GPRPLGRYGH 240
KISIIATTQM KTKLYVFGGQ FDDTYFNDLA VYDLSSFRRP DSHWEFLKPR TFTPPPITNF 300
TMISYDSKLW VFGGDTLQGL VNDVFMYDPA INDWFIIDTT GEKPPPVQEH ATVVYNDLMC 360
VVGGKDEHDA YLNSVYFLNL KSRKWFKLPV FTAGIPQGRS GHSLTLLKND KILIMGGDKF 420
DYARVEEYDL HTSDIDMQRG TIVYTLDLAR IKDLCPGVMD VPTDTPTPRN GNLDLATPVT 480
PTSHQTKNMN VPISAAPLAS APSPAPKDFS DADRLNREVH NRNVSTEHQN QSHPVNSESH 540
LIAEPNILTP YVPSESSQTP VMKITSNKPF DTPTIQKEPD LSETMDPTVG NQRIPSSIYG 600
DNLTPANQIK NNSPILETLP SNEIKTPQNG NIEEIKHLPD ADEKIDSTTT FDQEINGDKL 660
GTSSMSKVEE DGNVADEDDE IGVAQMASSP SKDQFKIKHY NESSELSQNN TEIDKLSEPV 720
DITIKKSDTA GHDSANHVID ASDEKNVSPM GDVPTDTKNE EASVPINRDA TTEVVDRALF 780
EKLRSELQSL KELTHEKALE AGAHIKELET ELWQLKSQKN SGTTKEIDEL DSVRLQSKCE 840
ILEADNHSLE DKVNELEELV NSKFLDIENL NEVIQFQNEK IKSLELEPNY KEKLEELQIE 900
HENLSRENER LKNESKQHNE DIINNVANYS SQLGSLISHW KENRANSSFL ESSSSLISVS 960
DENGEKTVGE PYGDQSRHHR VVINKLTNRL DDLLERSQEL TISKEKLSSE YHALKMEHSS 1020
LSQDVLVKEN EIKKIQNDYK ESISSMDSAS KALMVSQREL EKYKSLNKKL IDELDELKFK 1080
NGVCSENFEN GLRSTEESSN NVKNSNSIRE NQFNIKINDL KAELFITNQE RDDLKSEVLE 1140
LKKRLLNLEN NTKQVNEDAD SDLL 1164 
Gene Ontology
 GO:0005935; C:cellular bud neck; IDA:SGD.
 GO:0005934; C:cellular bud tip; IDA:SGD.
 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0043332; C:mating projection tip; IDA:SGD.
 GO:0000755; P:cytogamy; IMP:SGD.
 GO:0001100; P:negative regulation of exit from mitosis; IMP:SGD.
 GO:0008360; P:regulation of cell shape; IMP:SGD. 
Interpro
 IPR015915; Kelch-typ_b-propeller.
 IPR006652; Kelch_1. 
Pfam
 PF01344; Kelch_1 
SMART
  
PROSITE
  
PRINTS