UniProt Accession

 MPZL1_HUMAN; O95297; B2REB9; B2REC0; Q5R332; Q8IX11; Q9BWZ3; Q9NYK4; Q9UL20 

Genbank Protein ID

 AF087020; AF092424; AF092425; AF095726; AF095727; AF239756; AF478447; AF478448; AF478448; AY359019; AK297112; CR542160; AL356532; Z99943; Z99943; AL356532; Z99943; AL356532; Z99943; AL356532; Z99943; Z99943; AL356532; Z99943; AL356532; CH471067; BC007881 

Genbank Nucleotide ID

 AAC72231.1; AAD55346.1; AAD55347.1; AAF00083.1; AAF00084.1; AAF63499.1; AAO14645.1; AAO14647.1; AAO14646.1; AAQ89378.1; BAH12501.1; CAG46957.1; CAC36033.2; CAC36033.2; CAI20143.1; CAI20143.1; CAI20144.2; CAQ52583.1; CAQ52583.1; CAQ52584.1; CAQ52584.1; CAQ52610.1; CAQ52610.1; CAQ52611.1; CAQ52611.1; EAW90800.1; AAH07881.1 

Protein Name

 Myelin protein zero-like protein 1 

Protein Synonyms/Alias

 Protein zero-related 

Gene Name

 MPZL1 

Gene Synonyms/Alias

 PZR; UNQ849/PRO1787 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
212	SESLSPVKQAPRKSP	ubiquitination	[1]
227	SDTEGLVKSLPSGSH	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine- protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility. 

Sequence Annotation

 DOMAIN 36 146 Ig-like V-type.
 MOTIF 239 244 ITIM motif 1.
 MOTIF 261 266 ITIM motif 2.
 MOD_RES 208 208 Phosphoserine.
 MOD_RES 210 210 Phosphoserine.
 MOD_RES 219 219 Phosphoserine.
 MOD_RES 221 221 Phosphoserine.
 MOD_RES 241 241 Phosphotyrosine.
 MOD_RES 260 260 Phosphoserine.
 MOD_RES 263 263 Phosphotyrosine.
 CARBOHYD 50 50 N-linked (GlcNAc...).
 CARBOHYD 130 130 N-linked (GlcNAc...) (Potential).
 DISULFID 58 135 By similarity.  

Keyword

 Alternative splicing; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Phosphoprotein; Reference proteome; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 269 AA 

Protein Sequence

Gene Ontology

 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0005198; F:structural molecule activity; TAS:ProtInc.
 GO:0007267; P:cell-cell signaling; TAS:ProtInc.
 GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; TAS:ProtInc. 

Interpro

 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013106; Ig_V-set.
 IPR003596; Ig_V-set_subgr.
 IPR000920; Myelin_P0. 

Pfam

 PF07686; V-set 

SMART

 SM00406; IGv 

PROSITE

 PS50835; IG_LIKE 

PRINTS

 PR00213; MYELINP0.