UniProt Accession

 PDXK_MOUSE; Q8K183; Q3TM83; Q8BJQ5 

Genbank Protein ID

 AK039194; AK080846; AK145470; AK166078; AK166464; BC027745 

Genbank Nucleotide ID

 BAC30274.1; BAC38041.1; BAE26454.1; BAE38559.1; BAE38792.1; AAH27745.1 

Protein Name

 Pyridoxal kinase 

Protein Synonyms/Alias

 Pyridoxine kinase 

Gene Name

 Pdxk 

Gene Synonyms/Alias

 Pkh 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
76	LKVNDVNKYDYVLTG	ubiquitination	[1]
139	LLPVYRDKVVPVADI	ubiquitination	[1]
258	NLKVACEKTVSAMQH	acetylation	[2]
258	NLKVACEKTVSAMQH	ubiquitination	[1]
283	AEAGEGQKPSPAQLE	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Required for synthesis of pyridoxal-5-phosphate from vitamin B6 (By similarity). 

Sequence Annotation

 NP_BIND 186 187 ATP (By similarity).
 NP_BIND 223 234 ATP (By similarity).
 BINDING 12 12 Substrate (By similarity).
 BINDING 47 47 Substrate (By similarity).
 BINDING 127 127 Substrate (By similarity).
 BINDING 235 235 Substrate (By similarity).
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 59 59 Phosphoserine (By similarity).
 MOD_RES 164 164 Phosphoserine (By similarity).
 MOD_RES 213 213 Phosphoserine (By similarity).
 MOD_RES 285 285 Phosphoserine (By similarity).  

Keyword

 Acetylation; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Kinase; Metal-binding; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 312 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0031403; F:lithium ion binding; IEA:Compara.
 GO:0000287; F:magnesium ion binding; IEA:Compara.
 GO:0030955; F:potassium ion binding; IEA:Compara.
 GO:0008478; F:pyridoxal kinase activity; IEA:EC.
 GO:0030170; F:pyridoxal phosphate binding; IEA:Compara.
 GO:0031402; F:sodium ion binding; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:Compara.
 GO:0008283; P:cell proliferation; IEA:Compara.
 GO:0009443; P:pyridoxal 5'-phosphate salvage; IEA:InterPro. 

Interpro

 IPR011611; PfkB_dom.
 IPR004625; PyrdxlP_synth_PyrdxlKinase. 

Pfam

 PF00294; PfkB 

SMART

  

PROSITE

  

PRINTS