UniProt Accession

 NUP53_HUMAN; Q8NFH5; Q4ZFZ9; Q53S95; Q8TDJ1 

Genbank Protein ID

 AF514993; AF411516; AC064871; AC079249; BC047029; BC061698 

Genbank Nucleotide ID

 AAM76704.1; AAL86379.1; AAY24198.1; AAX88896.1; AAH47029.1; AAH61698.1 

Protein Name

 Nucleoporin NUP53 

Protein Synonyms/Alias

 35 kDa nucleoporin; Mitotic phosphoprotein 44; MP-44; Nuclear pore complex protein Nup53; Nucleoporin Nup35 

Gene Name

 NUP35 

Gene Synonyms/Alias

 MP44; NUP53 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
83	QPVVPAHKDKSGAPP	ubiquitination	[1, 2, 3]
85	VVPAHKDKSGAPPVR	ubiquitination	[2]
246	GVKPCIDKSVMESSD	ubiquitination	[2]
269	LAFTPPIKTLGTPTQ	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs). Can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC. 

Sequence Annotation

 DOMAIN 170 250 RRM Nup35-type.
 MOD_RES 66 66 Phosphoserine.
 MOD_RES 73 73 Phosphoserine.
 MOD_RES 99 99 Phosphoserine.
 MOD_RES 100 100 Phosphoserine.
 MOD_RES 106 106 Phosphothreonine.
 MOD_RES 121 121 Phosphoserine.
 MOD_RES 129 129 Phosphothreonine.
 MOD_RES 138 138 Phosphoserine.
 MOD_RES 265 265 Phosphothreonine.
 MOD_RES 273 273 Phosphothreonine.
 MOD_RES 279 279 Phosphoserine.
 MOD_RES 280 280 Phosphothreonine.
 MOD_RES 308 308 Phosphothreonine.  

Keyword

 Complete proteome; Membrane; mRNA transport; Nuclear pore complex; Nucleus; Phosphoprotein; Protein transport; Reference proteome; Translocation; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 326 AA 

Protein Sequence

Gene Ontology

 GO:0045111; C:intermediate filament cytoskeleton; IDA:HPA.
 GO:0031965; C:nuclear membrane; IDA:HPA.
 GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0005975; P:carbohydrate metabolic process; TAS:Reactome.
 GO:0019221; P:cytokine-mediated signaling pathway; TAS:Reactome.
 GO:0015758; P:glucose transport; TAS:Reactome.
 GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0010827; P:regulation of glucose transport; TAS:Reactome.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome.
 GO:0055085; P:transmembrane transport; TAS:Reactome.
 GO:0022415; P:viral reproductive process; TAS:Reactome. 

Interpro

 IPR017389; Nucleoporin_NUP53.
 IPR007846; RRM_NUP35_dom. 

Pfam

 PF05172; Nup35_RRM 

SMART

  

PROSITE

 PS51472; RRM_NUP35 

PRINTS