UniProt Accession

 ARCA_ECOLI; P0A9Q1; P03026; Q2M5R6 

Genbank Protein ID

 M10044; U14003; U00096; AP009048; L34010 

Genbank Nucleotide ID

 AAA23718.1; AAA97297.1; AAC77354.1; BAE78390.1; AAA23476.1 

Protein Name

 Aerobic respiration control protein ArcA 

Protein Synonyms/Alias

 Dye resistance protein 

Gene Name

 arcA 

Gene Synonyms/Alias

 cpxC; dye; fexA; msp; seg; sfrA; b4401; JW4364 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
89	GRDNEVDKILGLEIG	acetylation	[1]
103	GADDYITKPFNPREL	acetylation	[1]
138	RRSVESYKFNGWELD	acetylation	[1]
160	GPDGEQYKLPRSEFR	acetylation	[1]
178	HFCENPGKIQSRAEL	acetylation	[1]
187	QSRAELLKKMTGREL	acetylation	[1]
188	SRAELLKKMTGRELK	acetylation	[1]
195	KMTGRELKPHDRTVD	acetylation	[1]
210	VTIRRIRKHFESTPD	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Member of the two-component regulatory system ArcB/ArcA. Represses a wide variety of aerobic enzymes under anaerobic conditions. Controls the resistance of E.coli to dyes; required for expression of the alkaline phosphatase and sex factor F genes; It also may be involved in the osmoregulation of envelope proteins. When activated by ArcB, it negatively regulates the expression of genes of aerobic function. Activates the transcription of the plfB operon by binding to its promoter. 

Sequence Annotation

 DOMAIN 1 118 Response regulatory.
 MOD_RES 54 54 4-aspartylphosphate (By similarity).  

Keyword

 3D-structure; Activator; Complete proteome; Cytoplasm; Direct protein sequencing; DNA-binding; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation; Two-component regulatory system. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 238 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0000156; F:phosphorelay response regulator activity; IDA:EcoCyc.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:EcoCyc.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:EcoCyc.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:EcoCyc.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR011006; CheY-like_superfamily.
 IPR001867; Sig_transdc_resp-reg_C.
 IPR016032; Sig_transdc_resp-reg_C-effctor.
 IPR001789; Sig_transdc_resp-reg_receiver.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00072; Response_reg
 PF00486; Trans_reg_C 

SMART

 SM00448; REC
 SM00862; Trans_reg_C 

PROSITE

 PS50110; RESPONSE_REGULATORY 

PRINTS