UniProt Accession

 MIP18_HUMAN; Q9Y3D0 

Genbank Protein ID

 AF151886; AF161467; BC001733; BC005023 

Genbank Nucleotide ID

 AAD34123.1; AAF29082.1; AAH01733.1; AAH05023.1 

Protein Name

 Mitotic spindle-associated MMXD complex subunit MIP18 

Protein Synonyms/Alias

 MSS19-interacting protein of 18 kDa; Protein FAM96B 

Gene Name

 FAM96B 

Gene Synonyms/Alias

 MIP18; CGI-128; HSPC118 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
116	RSLPQRFKMDVHITP	ubiquitination	[1, 2]
134	ASEHAVNKQLADKER	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. 

Sequence Annotation

  

Keyword

 Chromosome partition; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 163 AA 

Protein Sequence

Gene Ontology

 GO:0097361; C:CIA complex; IDA:UniProtKB.
 GO:0071817; C:MMXD complex; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0007059; P:chromosome segregation; IMP:UniProtKB.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 

Interpro

 IPR002744; DUF59. 

Pfam

 PF01883; DUF59 

SMART

  

PROSITE

  

PRINTS