CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034832
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Mylk 
Protein Synonyms/Alias
  
Gene Name
 Mylk 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
1536TGKIWAGKFFKAYSAacetylation[1]
1539IWAGKFFKAYSAKEKacetylation[1]
1645NKTGTRIKLIDFGLAacetylation[1]
1847LEAVAEEKPHVKPYFacetylation[1]
1851AEEKPHVKPYFSKTIacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Repeat; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1961 AA 
Protein Sequence
MPGQLPGKTM GDVKLFASSH MSKTSHSVDP SRVSSLPLTE APAFILPPRN LCVKEGATAK 60
FEGRVRGHPE PQVTWHRNGQ TITNGGRFLL DGGVRGTFSL VIRGVREEDK GKYTCEASNG 120
SGARQVTVEL TVEGDLMKKH GQPVLSKASG FPGETRPSIW GECPPKFATK LGRAVVKEGQ 180
MGRFSCKITG RPPPQVTWLK GNVPLQPSAR VSMSEKNGMQ ILEIHEVTQD DMGTYTCMVV 240
NGSGKASMSA ELSIPGLDNA TRLSRGTKDP SPDIRKEVTN GISKDPETVA ESKNCSSPQK 300
SNFLAQATNS HLKSLQQPKL KPCEDSPRKV LQSSVLQKTS STIVLQASKV QPEVRAAGIG 360
ASGPGEERKS LTAPRQATPP TRQCGLGGSV GNKFITGNIP IENQRESRFP KFESQPQSQE 420
VTEGQTVKFT CEVSGIPKPE VGWFLEGIPV RRQEGIVEIY EDGTSHYLCL PRAGTRDSGR 480
YSCTASNTLG QVSCSWTLRV DRPSLTQTAP SFSSVLKDSV VIEGQDFVLR CSVRGTPAPQ 540
VTWLLNGQPI QFARSICEAG EAELHIQDAL PEDRGTYTCL AENALGQVSC SATVTVQEKK 600
GEGERAHRLP PAPSKLFAPI FLQGLSDLKV MDGSQVTMTV QVSGNPPPEV IWLHDGNEIQ 660
ESEDFHFEQK GGWHSLCIQE VFPEDTGTYT CEAWNSAGEV RTQAILTVQE PHDGTQPWFI 720
SKPRSVTASL GQSVLISCAI AGDPFPTVHW LRDGKALSRD HGHFELLQNE DVFTLVLKNV 780
QPWHAGQYEI LLKNRVGECS CQVSLMLHKG PSRVPPPRGR EPASCEGLCG GGVGAHGDAD 840
RDGTLRPCWP ARGQGWPEEE DGEDVRGLLK RRVETRLHTE EAIRQQEVGQ LDFRDLLGKK 900
VSTKTVSEDD LKDIPAEQMD FRANLQRQVK PKTVSEEERK VHSPQQVDFR SVLAKKGTPK 960
TPVPEKVPPQ KAATPDFRSV LGSKKKSPAE NGGNTAEVLN VKAGESPTPA GNAQPVGALK 1020
PIGNAKPAET LKSVGNAKPA ETLKPVGNAK PAETLKPVGN VKPAETLKPI ANAQPSGSPK 1080
PIANAQPIET QKSVANAKSA ETPKLAGKEE LKEVRNDVNC KKAHVGATGN EKRPESQGSA 1140
PVFKEKLQDV HVAEGEKLLL QCQVTSDPPA TVTWTLNGKT LKTTKFIILA QEGSLFSVSI 1200
EKALPEDRGL YKCVAKNSAG QAECSCQVTV DDAGTSENTK APEMKSRRPK SSLTPVLGTE 1260
SDATVKKKPA SKTPTKAAMP PQIIQFPEDQ KVRAGEPVEL FGKVTGTQPI TCTWMKFRKQ 1320
IQESENIRVE NSESGSKLTI LAARQEHCGC YTLVVENKLS SRQAQVNLTV VDKPDPPAGT 1380
PCASDIRSSS LTLSWYGSSY DGGSAVQSYN VEIWDTEDKV WTELATCRST SFNVQDLLPD 1440
REYKFRVRAV NVYGTSEPSQ ESELTAVGEK PEEPKDEVEV SDDDEKEPEV DYRTVTVNTE 1500
QKVSDVYDIE ERLGSGKFGQ VFRLVEKRTG KIWAGKFFKA YSAKEKENIR QEISIMNCLH 1560
HPKLVQCVDA FEEKANIVMV LEIVSGGELF ERIIDEDFEL TERECIKYMR QISEGVEYIH 1620
KQGIVHLDLK PENIMCVNKT GTRIKLIDFG LARRLENAGS LKVLFGTPEF VAPEVINYEP 1680
IGYATDMWSI GVICYILVSG LSPFMGDNDN ETLANVTSAT WDFDDEAFDE ISEDAKDFIS 1740
NLLKKDMKNR LDCTQCLQHP WLMKDTKNME AKKLSKDRMK KYMARRKWQK TGNAVRAIGR 1800
LSSMAMISGL SGRKSSTGSP TSPINAEKLE SEEDVSQAFL EAVAEEKPHV KPYFSKTIRD 1860
LEVVEGSAAR FDCKIEGYPD PEVVWFKDDQ SIRESRHFQI DYDEDGNCSL IISDVCGDDD 1920
AKYTCKAVNS LGEATCTAEL IVETMEEGEG EEGGEEEEEE E 1961 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro. 
Interpro
 IPR003961; Fibronectin_type3.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2.
 IPR011009; Kinase-like_dom.
 IPR020675; Myosin_light_ch_kinase-rel.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00041; fn3
 PF07679; I-set
 PF00069; Pkinase 
SMART
 SM00060; FN3
 SM00409; IG
 SM00408; IGc2
 SM00220; S_TKc 
PROSITE
 PS50853; FN3
 PS50835; IG_LIKE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS