CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042494
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Plasma membrane calcium-transporting ATPase 4 
Protein Synonyms/Alias
  
Gene Name
 ATP2B2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
1013SLYEGLEKPESRTSIubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Hydrolase; Membrane; Nucleotide-binding; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1099 AA 
Protein Sequence
AAIISLGLSF YHPPGEGNEG CATAQGGAED EGEAEAGWIE GAAILLSVIC VVLVTAFNDW 60
SKEKQFRGLQ SRIEQEQKFT VVRAGQVVQI PVAEIVVGDI AQVKYGDLLP ADGLFIQGND 120
LKIDESSLTG ESDQVRKSVD KDPMLLSGTH VMEGSGRMLV TAVGVNSQTG IIFTLLGAGG 180
EEEEKKDKKG KMQDGNVDAS QSKAKQQDGA AAMEMQPLKS AEGGDADDRK KASMHKKEKS 240
VLQGKLTKLA VQIGKAGLVM SAITVIILVL YFTVDTFVVN KKPWLPECTP VYVQYFVKFF 300
IIGVTVLVVA VPEGLPLAVT ISLAYSVKKM MKDNNLVRHL DACETMGNAT AICSDKTGTL 360
TTNRMTVVQA YVGDVHYKEI PDPSSINTKT MELLINAIAI NSAYTTKILP PEKEGALPRQ 420
VGNKTECGLL GFVLDLKQDY EPVRSQMPEE KLYKVYTFNS VRKSMSTVIK LPDESFRMYS 480
KGASEIVLKK CCKILNGAGE PRVFRPRDRD EMVKKVIEPM ACDGLRTICV AYRDFPSSPE 540
PDWDNENDIL NELTCICVVG IEDPVRPEVP EAIRKCQRAG ITVRMVTGDN INTARAIAIK 600
CGIIHPGEDF LCLEGKEFNR RIRNEKGEIE QERIDKIWPK LRVLARSSPT DKHTLVKGII 660
DSTHTEQRQV VAVTGDGTND GPALKKADVG FAMGIAGTDV AKEASDIILT DDNFSSIVKA 720
VMWGRNVYDS ISKFLQFQLT VNVVAVIVAF TGACITQDSP LKAVQMLWVN LIMDTFASLA 780
LATEPPTETL LLRKPYGRNK PLISRTMMKN ILGHAVYQLA LIFTLLFVGE KMFQIDSGRN 840
APLHSPPSEH YTIIFNTFVM MQLFNEINAR KIHGERNVFD GIFRNPIFCT IVLGTFAIQI 900
VIVQFGGKPF SCSPLQLDQW MWCIFIGLGE LVWGQVIATI PTSRLKFLKE AGRLTQKEEI 960
PEEELNEDVE EIDHAERELR RGQILWFRGL NRIQTQIRVV KAFRSSLYEG LEKPESRTSI 1020
HNFMAHPEFR IEDSQPHIPL IDDTDLEEDA ALKQNSSPPS SLNKNNSAID SGINLTTDTS 1080
KSATSSSPGS PIHSLETSL 1099 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0005388; F:calcium-transporting ATPase activity; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:InterPro. 
Interpro
 IPR022141; ATP_Ca_trans_C.
 IPR006408; ATPase_P-typ_Ca-transp_plasma.
 IPR006068; ATPase_P-typ_cation-transptr_C.
 IPR023299; ATPase_P-typ_cyto_domN.
 IPR018303; ATPase_P-typ_P_site.
 IPR023298; ATPase_P-typ_TM_dom.
 IPR008250; ATPase_P-typ_transduc_dom_A.
 IPR001757; Cation_transp_P_typ_ATPase.
 IPR023214; HAD-like_dom. 
Pfam
 PF12424; ATP_Ca_trans_C
 PF00689; Cation_ATPase_C
 PF00122; E1-E2_ATPase
 PF00702; Hydrolase 
SMART
  
PROSITE
 PS00154; ATPASE_E1_E2 
PRINTS
 PR00119; CATATPASE.