CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007699
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ISWI one complex protein 3 
Protein Synonyms/Alias
  
Gene Name
 IOC3 
Gene Synonyms/Alias
 YFR013W 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
114KKTTSIAKDGKPTLKacetylation[1]
293NLKSSSKKVFSNPLYubiquitination[2]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047] 
Functional Description
 Functions as component of the ISW1A complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW1A complex represses gene expression at initiation through specific positioning of a promoter proximal dinucleosome. 
Sequence Annotation
  
Keyword
 3D-structure; Complete proteome; Nucleus; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 787 AA 
Protein Sequence
MDSPSNSIQN LQQEAQGSSS AQLADHDHDR VSMAMPLQTD QSVSVSQSSD NLRRSRRVPK 60
PRTSIYDEYE EELKERANKP KRKRPAPPKK KAPSTQNSKS NDKVEKKKTT SIAKDGKPTL 120
KTNDKKVAPK PKPAHEQVEP ALIPSNWTSV IPLLTSDFKN QYSVISRLKN PNMKPVPYAG 180
DIIKLMAFIN KFSSFFHSDL QNLSFQDFEV GLDLYPGDPN GSAAGIVKGP EDTSLLLYPD 240
FMAIKDIVYC QDKMNLLFLS LLDLTFTENF DGKSAKKKGP LTTWENLKSS SKKVFSNPLY 300
RLRLVAREWG YPREWRQQLP SDQDISKPKT ALFEQDEQTP VVDPSHPEIL TPNIYTWNAN 360
EPLPLESNPL YNREMDKNGI LALKPMDRVV LLRALTDWCA SHSSAIHDEI YKLTHGKKDP 420
VFGIQTQQVP RYTIEGVDNT INQFKKLCSL IQSRYEIRSK KKHFVKQLKE GKKPDLSRKL 480
EILKEIKAEL KNAVKSEKDE LLFSLYDKWV PLFEGELPDQ PLANPFSERL YKLRLQEFFL 540
GRVPHIGDFY MPRLHSYGDS LEMSTFTDLR NLQALLSKFK NNEYNAFTLF ENDGQSMSAQ 600
FKLFYHDTPS LAHDVARGRN TSGKVYWYEL CHDSATLLEF LEFLDYKIVK PQDEKKEGNE 660
KEKEALNNEA HILEQKSTTD NNPSINTNPL PKDAKYNTAR KKLQILKEFL SDYYFILRQF 720
EQMKVQFADM KPGKRQLRRI QRQTVNYNTE YDSEEYVDDE EDDEADIYDD NDNDSSFDDG 780
RVKRQRT 787 
Gene Ontology
 GO:0016587; C:Isw1 complex; IPI:SGD.
 GO:0006200; P:ATP catabolic process; IDA:GOC.
 GO:0006338; P:chromatin remodeling; IPI:SGD.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS