UniProt Accession

 PLPP_HUMAN; Q96GD0; Q9UGY2 

Genbank Protein ID

 AY125047; Z83844; BC000320; BC009756; BC064922 

Genbank Nucleotide ID

 AAM94358.1; CAB63038.1; AAH00320.1; AAH09756.2; AAH64922.1 

Protein Name

 Pyridoxal phosphate phosphatase 

Protein Synonyms/Alias

 PLP phosphatase; Chronophin 

Gene Name

 PDXP 

Gene Synonyms/Alias

 CIN; PLP; PLPP 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
52	ERLARAGKAALFVSN	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho- tyrosine. Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PMP) and pyridoxine 5'-phosphate (PNP), with a highest activity with PLP followed by PNP. 

Sequence Annotation

 REGION 58 62 Substrate binding.
 ACT_SITE 25 25 Nucleophile.
 ACT_SITE 27 27 Proton donor (Probable).
 METAL 25 25 Magnesium.
 METAL 27 27 Magnesium; via carbonyl oxygen.
 METAL 238 238 Magnesium.
 BINDING 182 182 Substrate.
 BINDING 213 213 Substrate.  

Keyword

 3D-structure; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Hydrolase; Magnesium; Membrane; Metal-binding; Pyridoxal phosphate; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 296 AA 

Protein Sequence

Gene Ontology

 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0031258; C:lamellipodium membrane; IEA:UniProtKB-SubCell.
 GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
 GO:0031072; F:heat shock protein binding; IDA:MGI.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004721; F:phosphoprotein phosphatase activity; IDA:UniProtKB.
 GO:0004647; F:phosphoserine phosphatase activity; IEA:EC.
 GO:0033883; F:pyridoxal phosphatase activity; IEA:EC.
 GO:0031247; P:actin rod assembly; IDA:MGI.
 GO:0071318; P:cellular response to ATP; IDA:MGI.
 GO:0030836; P:positive regulation of actin filament depolymerization; IMP:UniProtKB.
 GO:0006470; P:protein dephosphorylation; IDA:UniProtKB.
 GO:0032465; P:regulation of cytokinesis; IMP:UniProtKB.
 GO:0007088; P:regulation of mitosis; IMP:UniProtKB. 

Interpro

 IPR023214; HAD-like_dom.
 IPR006357; HAD-SF_hydro_IIA.
 IPR023215; NPhePase-like_dom.
 IPR006349; PGP_euk. 

Pfam

 PF13344; Hydrolase_6 

SMART

  

PROSITE

  

PRINTS