CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030519
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Solute carrier family 25 member 46 
Protein Synonyms/Alias
 cDNA FLJ34108 fis, clone FCBBF3008251, highly similar to Human TB1 gene mRNA 
Gene Name
 SLC25A46 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
47LPREVLHKWSPKQIGubiquitination[1, 2]
51VLHKWSPKQIGEHLLubiquitination[1, 3, 4]
95TGILECVKEGIGRVIubiquitination[1, 4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Membrane; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 272 AA 
Protein Sequence
MYSFNKTQGP RALWKGMGST FIVQGVTLGA EGIISEFTPL PREVLHKWSP KQIGEHLLLK 60
SLTYVVAMPF YSASLIETVQ SEIIRDNTGI LECVKEGIGR VIGMGVPHSK RLLPLLSLIF 120
PTVLHGVLHY IISSVIQKFV LLILKRKTYN SHLAESTSPV QSMLDAYFPE LIANFAASLC 180
SDVILYPLET VLHRLHIQGT RTIIDNTDLG YEVLPINTQY EGMRDCINTI RQEEGVFGFY 240
KGFGAVIIQY TLHAAVLQIT KIIYSTLLQN NI 272 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0006810; P:transport; IEA:UniProtKB-KW. 
Interpro
 IPR018108; Mitochondrial_sb/sol_carrier.
 IPR023395; Mt_carrier_dom. 
Pfam
 PF00153; Mito_carr 
SMART
  
PROSITE
 PS50920; SOLCAR 
PRINTS