UniProt Accession

 TRA2B_HUMAN; P62995; B4DVK2; D3DNU3; O15449; Q15815; Q64283 

Genbank Protein ID

 U61267; U87836; AF057159; AF057159; AF057159; U68063; AK301118; CH471052; CH471052; CH471052; BC000160; BC000451; BC005898 

Genbank Nucleotide ID

 AAC28242.1; AAB69763.1; AAD19277.1; AAD19278.1; AAD19279.1; AAB08701.1; BAG62714.1; EAW78204.1; EAW78205.1; EAW78208.1; AAH00160.1; AAH00451.1; AAH05898.1 

Protein Name

 Transformer-2 protein homolog beta 

Protein Synonyms/Alias

 TRA-2 beta; TRA2-beta; hTRA2-beta; Splicing factor, arginine/serine-rich 10; Transformer-2 protein homolog B 

Gene Name

 TRA2B 

Gene Synonyms/Alias

 SFRS10 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
40	DLREVFSKYGPIADV	ubiquitination	[1]
97	RVDFSITKRPHTPTP	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre- mRNA. 

Sequence Annotation

 DOMAIN 118 196 RRM.
 REGION 193 230 Linker.
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 2 2 Phosphoserine.
 MOD_RES 4 4 Phosphoserine.
 MOD_RES 14 14 Phosphoserine.
 MOD_RES 50 50 Phosphoserine (By similarity).
 MOD_RES 52 52 Phosphoserine (By similarity).
 MOD_RES 54 54 Phosphoserine (By similarity).
 MOD_RES 56 56 Phosphoserine (By similarity).
 MOD_RES 83 83 Phosphoserine.
 MOD_RES 85 85 Phosphoserine (By similarity).
 MOD_RES 95 95 Phosphoserine.
 MOD_RES 97 97 Phosphoserine.
 MOD_RES 99 99 Phosphoserine.
 MOD_RES 103 103 Phosphothreonine.
 MOD_RES 201 201 Phosphothreonine.
 MOD_RES 203 203 Phosphothreonine.
 MOD_RES 241 241 Dimethylated arginine.
 MOD_RES 264 264 Phosphoserine (By similarity).
 MOD_RES 266 266 Phosphoserine (By similarity).
 MOD_RES 284 284 Phosphoserine (By similarity).  

Keyword

 3D-structure; Acetylation; Activator; Alternative splicing; Complete proteome; Direct protein sequencing; Methylation; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repressor; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 288 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0003729; F:mRNA binding; IDA:UniProtKB.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0000398; P:mRNA splicing, via spliceosome; IDA:UniProtKB.
 GO:0048026; P:positive regulation of mRNA splicing, via spliceosome; IDA:UniProtKB.
 GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IDA:UniProtKB. 

Interpro

 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 

Pfam

 PF00076; RRM_1 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS