CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022443
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial 
Protein Synonyms/Alias
 2-polyprenyl-6-hydroxyphenyl methylase; 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase; DHHB methyltransferase; DHHB-MT; DHHB-MTase; 3-demethylubiquinone-10 3-methyltransferase; Dihydroxyhexaprenylbenzoate methyltransferase 
Gene Name
 COQ3 
Gene Synonyms/Alias
 UG0215E05 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
182DPVDENIKTAQCHKSubiquitination[1]
196SFDPVLDKRIEYRVCubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Methyltransferase; Mitochondrion; Polymorphism; Reference proteome; S-adenosyl-L-methionine; Transferase; Transit peptide; Ubiquinone biosynthesis. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 369 AA 
Protein Sequence
MWSGRKLGSS GGWFLRVLGP GGCNTKAARP LISSAVYVKN QLSGTLQIKP GVFNEYRTIW 60
FKSYRTIFSC LNRIKSFRYP WARLYSTSQT TVDSGEVKTF LALAHKWWDE QGVYAPLHSM 120
NDLRVPFIRD NLLKTIPNHQ PGKPLLGMKI LDVGCGGGLL TEPLGRLGAS VIGIDPVDEN 180
IKTAQCHKSF DPVLDKRIEY RVCSLEEIVE ETAETFDAVV ASEVVEHVID LETFLQCCCQ 240
VLKPGGSLFI TTINKTQLSY ALGIVFSEQI ASIVPKGTHT WEKFVSPETL ESILESNGLS 300
VQTVVGMLYN PFSGYWHWSE NTSLNYAAYA VKSRVQEHPA SAEFVLKGET EELQANACTN 360
PAVHEKLKK 369 
Gene Ontology
 GO:0005759; C:mitochondrial matrix; TAS:Reactome.
 GO:0008425; F:2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity; IEA:InterPro.
 GO:0008689; F:3-demethylubiquinone-9 3-O-methyltransferase activity; IEA:EC.
 GO:0004395; F:hexaprenyldihydroxybenzoate methyltransferase activity; IEA:EC.
 GO:0008171; F:O-methyltransferase activity; TAS:ProtInc.
 GO:0006071; P:glycerol metabolic process; IGI:UniProtKB.
 GO:0006744; P:ubiquinone biosynthetic process; IGI:UniProtKB. 
Interpro
 IPR013216; Methyltransf_11.
 IPR010233; UbiG_MeTrfase. 
Pfam
 PF08241; Methyltransf_11 
SMART
  
PROSITE
  
PRINTS