CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023504
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nuclear receptor corepressor 2 
Protein Synonyms/Alias
 N-CoR2; Silencing mediator of retinoic acid and thyroid hormone receptor; SMRT; SMRTe; T3 receptor-associating factor; TRAC; Thyroid-, retinoic-acid-receptor-associated corepressor 
Gene Name
 Ncor2 
Gene Synonyms/Alias
 Smrt 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
668ILQQHKLKMEKERNAsumoylation[1]
Reference
 [1] Aberrant expression and modification of silencing mediator of retinoic acid and thyroid hormone receptors involved in the pathogenesis of tumoral cortisol resistance.
 Jiang J, Li N, Wang X, Lu Y, Bi Y, Wang W, Li X, Ning G.
 Endocrinology. 2010 Aug;151(8):3697-705. [PMID: 20555024] 
Functional Description
 Transcriptional corepressor of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. 
Sequence Annotation
 DOMAIN 427 478 SANT 1.
 DOMAIN 606 657 SANT 2.
 REGION 254 312 Interaction with SIN3A/B (By similarity).
 REGION 2086 2090 Required for interaction with RARA in the
 MOTIF 2094 2098 CORNR box of ID1.
 MOTIF 2296 2300 CORNR box of ID2.
 MOD_RES 54 54 Phosphoserine (By similarity).
 MOD_RES 67 67 Phosphoserine (By similarity).
 MOD_RES 149 149 Phosphoserine.
 MOD_RES 152 152 Phosphoserine.
 MOD_RES 215 215 Phosphoserine (By similarity).
 MOD_RES 549 549 Phosphothreonine.
 MOD_RES 550 550 Phosphoserine.
 MOD_RES 747 747 Phosphoserine (By similarity).
 MOD_RES 750 750 Phosphoserine (By similarity).
 MOD_RES 863 863 Phosphoserine.
 MOD_RES 878 878 N6-acetyllysine (By similarity).
 MOD_RES 938 938 Phosphoserine.
 MOD_RES 955 955 Phosphoserine (By similarity).
 MOD_RES 958 958 N6-acetyllysine (By similarity).
 MOD_RES 1181 1181 N6-acetyllysine (By similarity).
 MOD_RES 1209 1209 N6-acetyllysine (By similarity).
 MOD_RES 1220 1220 Phosphoserine (By similarity).
 MOD_RES 1350 1350 Phosphothreonine (By similarity).
 MOD_RES 1406 1406 Phosphothreonine.
 MOD_RES 1449 1449 Phosphoserine (By similarity).
 MOD_RES 1749 1749 Phosphoserine.
 MOD_RES 1819 1819 Phosphoserine (By similarity).
 MOD_RES 1920 1920 N6-acetyllysine (By similarity).
 MOD_RES 1963 1963 Phosphoserine (By similarity).
 MOD_RES 1983 1983 N6-acetyllysine (By similarity).
 MOD_RES 2004 2004 Phosphoserine (By similarity).
 MOD_RES 2012 2012 Phosphoserine (By similarity).
 MOD_RES 2015 2015 Phosphoserine (By similarity).
 MOD_RES 2016 2016 Phosphoserine (By similarity).
 MOD_RES 2020 2020 Phosphothreonine (By similarity).
 MOD_RES 2161 2161 Phosphoserine (By similarity).
 MOD_RES 2181 2181 Phosphoserine (By similarity).
 MOD_RES 2215 2215 Phosphoserine (By similarity).
 MOD_RES 2410 2410 Phosphoserine.  
Keyword
 Acetylation; Alternative splicing; Coiled coil; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2472 AA 
Protein Sequence
MSGSTQPVAQ TWRAAEPRYP PHGISYPVQI ARSHTDVGLL EYQHHPRDYT SHLSPGSIIQ 60
PQRRRPSLLS EFQPGSERSQ ELHLRPESRT FLPELGKPDI EFTESKRPRL ELLPDTLLRP 120
SPLLATGQPS GSEDLTKDRS LAGKLEPVSP PSPPHADPEL ELAPSRLSKE ELIQNMDRVD 180
REITMVEQQI SKLKKKQQQL EEEAAKPPEP EKPVSPPPIE SKHRSLVQII YDENRKKAEA 240
AHRILEGLGP QVELPLYNQP SDTRQYHENI KINQAMRKKL ILYFKRRNHA RKQWEQRFCQ 300
RYDQLMEAWE KKVERIENNP RRRAKESKVR EYYEKQFPEI RKQRELQERM QSRVGQRGSG 360
LSMSAARSEH EVSEIIDGLS EQENLEKQMR QLAVIPPMLY DADQQRIKFI NMNGLMDDPM 420
KVYKDRQVTN MWSEQERDTF REKFMQHPKN FGLIASFLER KTVAECVLYY YLTKKNENYK 480
SLVRRSYRRR GKSQQQQQQQ QQQQQQQMAR SSQEEKEEKE KEKEADKEEE KQDAENEKEE 540
LSKEKTDDTS GEDNDEKEAV ASKGRKTANS QGRRKGRITR SMANEANHEE TATPQQSSEL 600
ASMEMNESSR WTEEEMETAK KGLLEHGRNW SAIARMVGSK TVSQCKNFYF NYKKRQNLDE 660
ILQQHKLKME KERNARRKKK KTPAAASEET AFPPAAEDEE MEASGASANE EELAEEAEAS 720
QASGNEVPRV GECSGPAAVN NSSDTESVPS PRSEATKDTG PKPTGTEALP AATQPPVPPP 780
EEPAVAPAEP SPVPDASGPP SPEPSPSPAA PPATVDKDEQ EAPAAPAPQT EDAKEQKSEA 840
EEIDVGKPEE PEASEEPPES VKSDHKEETE EEPEDKAKGT EAIETVSEAP LKVEEAGSKA 900
AVTKGSSSGA TQDSDSSATC SADEVDEPEG GDKGRLLSPR PSLLTPAGDP RASTSPQKPL 960
DLKQLKQRAA AIPPIVTKVH EPPREDTVPP KPVPPVPPPT QHLQPEGDVS QQSGGSPRGK 1020
SRSPVPPAEK EAEKPAFFPA FPTEGPKLPT EPPRWSSGLP FPIPPREVIK TSPHAADPSA 1080
FSYTPPGHPL PLGLHDSARP VLPRPPISNP PPLISSAKHP GVLERQLGAI SQQGMSVQLR 1140
VPHSEHAKAP MGPLTMGLPL AVDPKKLGTA LGSATSGSIT KGLPSTRAAD GPSYRGSITH 1200
GTPADVLYKG TISRIVGEDS PSRLDRARED TLPKGHVIYE GKKGHVLSYE GGMSVSQCSK 1260
EDGRSSSGPP HETAAPKRTY DMMEGRVGRT VTSASIEGLM GRAIPEQHSP HLKEQHHIRG 1320
SITQGIPRSY VEAQEDYLRR EAKLLKREGT PPPPPPPRDL TETYKPRPLD PLGPLKLKPT 1380
HEGVVATVKE AGRSIHEIPR EELRRTPELP LAPRPLKEGS ITQGTPLKYD SGAPSTGTKK 1440
HDVRSIIGSP GRPFPALHPL DIMADARALE RACYEESLKS RSGTSSGAGG SITRGAPVVV 1500
PELGKPRQSP LTYEDHGAPF TSHLPRGSPV TTREPTPRLQ EGSLLSSKAS QDRKLTSTPR 1560
EIAKSPHSTV PEHHPHPISP YEHLLRGVTG VDLYRGHIPL AFDPTSIPRG IPLEAAAAAY 1620
YLPRHLAPSP TYPHLYPPYL IRGYPDTAAL ENRQTIINDY ITSQQMHHNA ASAMAQRADM 1680
LRGLSPRESS LALNYAAGPR GIIDLSQVPH LPVLVPPTPG TPATAIDRLA YLPTAPPPFS 1740
SRHSSSPLSP GGPTHLAKPT ATSSSERERE RERERDKSIL TSTTTVEHAP IWRPGTEQSS 1800
GAGGSSRPAS HTHQHSPISP RTQDALQQRP SVLHNTSMKG VVTSVEPGTP TVLRWARSTS 1860
TSSPVRPAAT FPPATHCPLG GTLEGVYPTL MEPVLLPKET SRVARPERPR VDAGHAFLTK 1920
PPAREPASSP SKSSEPRSLA PPSSSHTAIA RTPAKNLAPH HASPDPPAPT SASDLHREKT 1980
QSKPFSIQEL ELRSLGYHSG AGYSPDGVEP ISPVSSPSLT HDKGLSKPLE ELEKSHLEGE 2040
LRHKQPGPMK LSAEAAHLPH LRPLPESQPS SSPLLQTAPG IKGHQRVVTL AQHISEVITQ 2100
DYTRHHPQQL SGPLPAPLYS FPGASCPVLD LRRPPSDLYL PPPDHGTPAR GSPHSEGGKR 2160
SPEPSKTSVL GSSEDAIEPV SPPEGMTEPG HARSTAYPLL YRDGEQGEPR MGSKSPGNTS 2220
QPPAFFSKLT ESNSAMVKSK KQEINKKLNT HNRNEPEYNI GQPGTEIFNM PAITGAGLMT 2280
CRSQAVQEHA STNMGLEAII RKALMGKYDQ WEEPPPLGAN AFNPLNASAS LPAAAMPITT 2340
ADGRSDHALT SPGGGGKAKV SGRPSSRKAK SPAPGLASGD RPPSVSSVHS EGDCNRRTPL 2400
TNRVWEDRPS SAGSTPFPYN PLIMRLQAGV MASPPPPGLA AGSGPLAGPH HAWDEEPKPL 2460
LCSQYETLSD SE 2472 
Gene Ontology
 GO:0000118; C:histone deacetylase complex; IDA:MGI.
 GO:0016604; C:nuclear body; IDA:MGI.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
 GO:0003714; F:transcription corepressor activity; IDA:UniProtKB.
 GO:0021846; P:cell proliferation in forebrain; IMP:MGI.
 GO:0042593; P:glucose homeostasis; IMP:MGI.
 GO:0003007; P:heart morphogenesis; IMP:MGI.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0045599; P:negative regulation of fat cell differentiation; IMP:MGI.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0021537; P:telencephalon development; IMP:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0050872; P:white fat cell differentiation; IMP:MGI. 
Interpro
 IPR009057; Homeodomain-like.
 IPR001005; SANT/Myb.
 IPR017884; SANT_dom. 
Pfam
 PF00249; Myb_DNA-binding 
SMART
 SM00717; SANT 
PROSITE
 PS51293; SANT 
PRINTS