CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014353
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Forkhead box protein C1 
Protein Synonyms/Alias
 Forkhead-related protein FKHL7; Forkhead-related transcription factor 3; FREAC-3; Mesoderm/mesenchyme forkhead 1; MF-1; Transcription factor FKH-1 
Gene Name
 Foxc1 
Gene Synonyms/Alias
 Fkh1; Fkhl7; Freac3; Mf1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
229PVRIQDIKTENGTCPsumoylation[1]
258GSAATVPKIESPDSSsumoylation[1]
Reference
 [1] Small ubiquitin-like modifier (SUMO) modification mediates function of the inhibitory domains of developmental regulators FOXC1 and FOXC2.
 Danciu TE, Chupreta S, Cruz O, Fox JE, Whitman M, Iñiguez-Lluhí JA.
 J Biol Chem. 2012 May 25;287(22):18318-29. [PMID: 22493429] 
Functional Description
 Transcriptional regulator. Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye (By similarity). 
Sequence Annotation
 DNA_BIND 77 168 Fork-head.
 MOD_RES 237 237 Phosphoserine (By similarity).
 MOD_RES 243 243 Phosphoserine (By similarity).
 MOD_RES 320 320 Phosphoserine (By similarity).
 MOD_RES 521 521 Phosphoserine (By similarity).  
Keyword
 Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 553 AA 
Protein Sequence
MQARYSVSSP NSLGVVPYLG GEQSYYRAAA AAAGGGYTAM PAPMSVYSHP AHAEQYPGSM 60
ARAYGPYTPQ PQPKDMVKPP YSYIALITMA IQNAPDKKIT LNGIYQFIMD RFPFYRDNKQ 120
GWQNSIRHNL SLNECFVKVP RDDKKPGKGS YWTLDPDSYN MFENGSFLRR RRRFKKKDAV 180
KDKEEKGRLH LQEPPPPQAG RQPAPAPPEQ AEGSAPGPQP PPVRIQDIKT ENGTCPSPPQ 240
PLSPAAALGS GSAATVPKIE SPDSSSSSLS SGSSPPGSLP SARPLSLDAA EPAPPPQPAP 300
PPHHSQGFSV DNIMTSLRGS PQGSAAELGS GLLASAAASS RAGIAPPLAL GAYSPGQSSL 360
YSSPCSQSSS AGSSGGGGGG GGGGGGSSSA AGTGGAATYH CNLQAMSLYA AGERGGHLQG 420
PAGGAGSAAV DDPLPDYSLP PATSSSSSSL SHGGGGQEAS HHPASHQGRL TSWYLNQAGG 480
DLGHLASAAA AAAAAGYPGQ QQNFHSVREM FESQRIGLNN SPVNGNSSCQ MAFPASQSLY 540
RTSGAFVYDC SKF 553 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005720; C:nuclear heterochromatin; ISS:UniProtKB.
 GO:0005667; C:transcription factor complex; IBA:RefGenome.
 GO:0031490; F:chromatin DNA binding; IBA:RefGenome.
 GO:0008301; F:DNA binding, bending; ISS:UniProtKB.
 GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.
 GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IDA:MGI.
 GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
 GO:0008134; F:transcription factor binding; ISS:UniProtKB.
 GO:0044212; F:transcription regulatory region DNA binding; IDA:BHF-UCL.
 GO:0048844; P:artery morphogenesis; IMP:MGI.
 GO:0001974; P:blood vessel remodeling; IGI:MGI.
 GO:0007420; P:brain development; IMP:MGI.
 GO:0043010; P:camera-type eye development; IMP:MGI.
 GO:0060038; P:cardiac muscle cell proliferation; IGI:MGI.
 GO:0030199; P:collagen fibril organization; IMP:MGI.
 GO:0035050; P:embryonic heart tube development; IGI:MGI.
 GO:0008354; P:germ cell migration; IMP:MGI.
 GO:0030203; P:glycosaminoglycan metabolic process; IMP:MGI.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0032808; P:lacrimal gland development; IMP:MGI.
 GO:0001946; P:lymphangiogenesis; IBA:RefGenome.
 GO:0001656; P:metanephros development; IBA:RefGenome.
 GO:0043066; P:negative regulation of apoptotic process; IGI:MGI.
 GO:0045930; P:negative regulation of mitotic cell cycle; ISS:UniProtKB.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IBA:RefGenome.
 GO:0014032; P:neural crest cell development; IGI:MGI.
 GO:0014034; P:neural crest cell fate commitment; IBA:RefGenome.
 GO:0007219; P:Notch signaling pathway; IGI:MGI.
 GO:0042475; P:odontogenesis of dentin-containing tooth; ISS:UniProtKB.
 GO:0001503; P:ossification; IMP:MGI.
 GO:0001541; P:ovarian follicle development; IMP:MGI.
 GO:0048343; P:paraxial mesodermal cell fate commitment; IBA:RefGenome.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
 GO:0050880; P:regulation of blood vessel size; IGI:MGI.
 GO:0046620; P:regulation of organ growth; IGI:MGI.
 GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IBA:RefGenome.
 GO:0001501; P:skeletal system development; IMP:MGI.
 GO:0001756; P:somitogenesis; IGI:UniProtKB.
 GO:0001657; P:ureteric bud development; IMP:MGI.
 GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; IGI:MGI.
 GO:0001570; P:vasculogenesis; IBA:RefGenome.
 GO:0055010; P:ventricular cardiac muscle tissue morphogenesis; IGI:MGI. 
Interpro
 IPR001766; TF_fork_head.
 IPR018122; TF_fork_head_CS.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF00250; Fork_head 
SMART
 SM00339; FH 
PROSITE
 PS00657; FORK_HEAD_1
 PS00658; FORK_HEAD_2
 PS50039; FORK_HEAD_3 
PRINTS
 PR00053; FORKHEAD.