CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010022
UniProt Accession
Genbank Protein ID
 U00089 
Genbank Nucleotide ID
Protein Name
 Fructose-bisphosphate aldolase 
Protein Synonyms/Alias
 FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase 
Gene Name
 fba 
Gene Synonyms/Alias
 tsr; MPN_025; MP129 
Created Date
 July 27, 2013 
Organism
 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 
NCBI Taxa ID
 272634 
Lysine Modification
Position
Peptide
Type
References
54STSEGALKYISGHQVacetylation[1]
165CKQIATLKPDALAAGacetylation[1]
248IREYVEAKKDLDTHNacetylation[1]
256KDLDTHNKGYDPRKLacetylation[1]
Reference
 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819] 
Functional Description
 Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis (By similarity). 
Sequence Annotation
 REGION 207 209 Dihydroxyacetone phosphate binding (By
 REGION 228 231 Dihydroxyacetone phosphate binding (By
 ACT_SITE 84 84 Proton donor (By similarity).
 METAL 85 85 Zinc 1; catalytic (By similarity).
 METAL 105 105 Zinc 2 (By similarity).
 METAL 135 135 Zinc 2 (By similarity).
 METAL 177 177 Zinc 1; catalytic (By similarity).
 METAL 206 206 Zinc 1; catalytic (By similarity).
 BINDING 49 49 Glyceraldehyde 3-phosphate (By
 BINDING 178 178 Dihydroxyacetone phosphate; via amide  
Keyword
 Complete proteome; Glycolysis; Lyase; Metal-binding; Reference proteome; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 288 AA 
Protein Sequence
MLVNIKQMLQ HAKQHHYAVP HININNYEWA KAVLTAAQQA KSPIIVSTSE GALKYISGHQ 60
VVVPMVKGLV DALKITVPVA LHLDHGSYEG CKAALQAGFS SIMFDGSHLP FQENFTKSKE 120
LIELAKQTNA SVELEVGTLG GEEDGIVGQG ELANIEECKQ IATLKPDALA AGIGNIHGLY 180
PDNWKGLNYE LIEAIAKATN LPLVLHGGSG IPEADVKKAI GLGISKLNIN TECQLAFAKA 240
IREYVEAKKD LDTHNKGYDP RKLLKSPTQA IVDCCLEKMQ LCGSTNKA 288 
Gene Ontology
 GO:0004332; F:fructose-bisphosphate aldolase activity; IEA:EC.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0030388; P:fructose 1,6-bisphosphate metabolic process; IEA:InterPro.
 GO:0006096; P:glycolysis; IEA:UniProtKB-UniPathway. 
Interpro
 IPR013785; Aldolase_TIM.
 IPR011289; Fruc_bis_ald_class-2.
 IPR000771; Ketose_bisP_aldolase_II. 
Pfam
 PF01116; F_bP_aldolase 
SMART
  
PROSITE
 PS00602; ALDOLASE_CLASS_II_1
 PS00806; ALDOLASE_CLASS_II_2 
PRINTS