UniProt Accession

 MAP6_MOUSE; Q7TSJ2; O55129; O70586; O70587; Q78DV4; Q78DV5 

Genbank Protein ID

 Y14754; Y14755; Y14756; Y16008; Y16032; BC053039 

Genbank Nucleotide ID

 CAA75049.1; CAA75049.1; CAA75049.1; CAA75930.1; CAA75989.1; AAH53039.1 

Protein Name

 Microtubule-associated protein 6 

Protein Synonyms/Alias

 MAP-6; Stable tubule-only polypeptide; STOP 

Gene Name

 Map6 

Gene Synonyms/Alias

 Mtap6 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
21	RFWNQLDKADIAVPL	ubiquitination	[1]
32	AVPLVFTKYSEATEH	ubiquitination	[1]
156	ERETQYQKDFRAWPL	ubiquitination	[1]
174	GDHPWIPKPVQIPAT	ubiquitination	[1]
193	QPVLGVPKRRPQSQE	ubiquitination	[1]
226	AGVLAAGKASGVDQR	ubiquitination	[1]
238	DQRDTRRKAGPAWMV	ubiquitination	[1]
254	RNEGHEEKPLPPAQS	ubiquitination	[1]
272	EGGPAAGKASGADQR	ubiquitination	[1]
300	RSEGHEEKPLPPAQS	ubiquitination	[1]
318	EGGPAAGKASGADQR	ubiquitination	[1]
364	EGGPAAGKASGADER	ubiquitination	[1]
376	DERDTRRKAGPAWMV	ubiquitination	[1]
406	GTGPEGGKGRAVADA	ubiquitination	[1]
441	FRAWTDIKPVKPIKA	ubiquitination	[1]
444	WTDIKPVKPIKAKPQ	ubiquitination	[1]
458	QYKPPDDKMVHETSY	ubiquitination	[1]
475	QFKGEANKPSAADNK	ubiquitination	[1]
482	KPSAADNKAMDRRRI	ubiquitination	[1]
498	SLYSEPFKECPKVEK	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Involved in microtubule stabilization in many cell types, including neuronal cells. Specifically has microtubule cold stabilizing activity. 

Sequence Annotation

 REPEAT 222 267 Mc-1.
 REPEAT 268 313 Mc-2.
 REPEAT 314 359 Mc-3.
 REPEAT 360 405 Mc-4.
 REGION 1 15 Calmodulin-binding (By similarity).
 REGION 116 139 Mn 1 (By similarity).
 REGION 124 138 Calmodulin-binding (By similarity).
 REGION 151 174 Mn 2 (By similarity).
 REGION 160 174 Calmodulin-binding (By similarity).
 REGION 187 201 Calmodulin-binding (By similarity).
 REGION 222 405 4 X approximate tandem repeat Mc.
 REGION 235 249 Calmodulin-binding (By similarity).
 REGION 280 294 Calmodulin-binding (By similarity).
 REGION 325 339 Calmodulin-binding (By similarity).
 REGION 375 389 Calmodulin-binding (By similarity).
 REGION 427 450 Mn 3 (By similarity).
 REGION 435 449 Calmodulin-binding (By similarity).
 REGION 486 500 Calmodulin-binding (By similarity).
 REGION 513 527 Calmodulin-binding (By similarity).
 MOD_RES 108 108 Phosphoserine.
 MOD_RES 141 141 Phosphotyrosine.
 MOD_RES 632 632 Phosphoserine.
 MOD_RES 687 687 Phosphoserine.
 MOD_RES 832 832 Phosphoserine.
 MOD_RES 905 905 Phosphoserine.
 LIPID 5 5 S-palmitoyl cysteine (By similarity).
 LIPID 10 10 S-palmitoyl cysteine (By similarity).
 LIPID 11 11 S-palmitoyl cysteine (By similarity).  

Keyword

 Alternative promoter usage; Alternative splicing; Calmodulin-binding; Complete proteome; Cytoplasm; Cytoskeleton; Golgi apparatus; Lipoprotein; Microtubule; Palmitate; Phosphoprotein; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 906 AA 

Protein Sequence

Gene Ontology

 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0008017; F:microtubule binding; IDA:MGI.
 GO:0007026; P:negative regulation of microtubule depolymerization; IEA:InterPro. 

Interpro

 IPR024963; STOP/FAM154.
 IPR007882; STOP/MAP6. 

Pfam

 PF05217; STOP 

SMART

  

PROSITE

  

PRINTS