UniProt Accession

 PEX19_YEAST; Q07418; D6VRT2 

Genbank Protein ID

 Z74113; BK006938 

Genbank Nucleotide ID

 CAA98630.1; DAA11792.1 

Protein Name

 Peroxisomal membrane protein import receptor PEX19 

Protein Synonyms/Alias

 Peroxin-19 

Gene Name

 PEX19 

Gene Synonyms/Alias

 PAS12; YDL065C; D2528 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
93	NGNENNVKTEDFNKL	ubiquitination	[1]
129	LKSNSTDKGTVNGSN	ubiquitination	[1]
204	AENQFDLKDGEMDDA	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Required for proper post-translational import and stabilization of peroxisomal membrane proteins (PMPs). Acts as a cytosolic import receptor for PMPs and delivers them to the docking factor PEX3 at the peroxisomal membrane for subsequent insertion into the membrane. Acts as a chaperone in stabilizing or maintaining PMPs in the lipid bilayer. Directs PEX17, a peripheral component of the peroxisomal matrix protein translocation machinery, to peroxisomes. Stabilizes VPS1, a protein required for peroxisomal fission, at the peroxisomal membrane. Also acts in conjunction with PEX3 in the formation of peroxisomes from preperoxisomal compartments at the endoplasmic reticulum during de novo peroxisome synthesis, probably via the import of additional PMPs. 

Sequence Annotation

 MOD_RES 62 62 Phosphoserine.
 MOD_RES 304 304 Phosphoserine.
 MOD_RES 339 339 Cysteine methyl ester (Probable).
 LIPID 339 339 S-farnesyl cysteine.  

Keyword

 Complete proteome; Cytoplasm; Endoplasmic reticulum; Lipoprotein; Membrane; Methylation; Peroxisome; Peroxisome biogenesis; Phosphoprotein; Prenylation; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 342 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:SGD.
 GO:0005783; C:endoplasmic reticulum; IDA:SGD.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0005778; C:peroxisomal membrane; IDA:SGD.
 GO:0033328; F:peroxisome membrane targeting sequence binding; IPI:SGD.
 GO:0032581; P:ER-dependent peroxisome organization; IMP:SGD.
 GO:0045033; P:peroxisome inheritance; IPI:SGD.
 GO:0032527; P:protein exit from endoplasmic reticulum; IMP:SGD.
 GO:0045046; P:protein import into peroxisome membrane; IMP:SGD.
 GO:0050821; P:protein stabilization; IPI:SGD. 

Interpro

 IPR006708; Pex19. 

Pfam

 PF04614; Pex19 

SMART

  

PROSITE

  

PRINTS