| Tag | Content |
|---|
| CPLM ID | CPLM-011146 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Something about silencing protein 4 |
Protein Synonyms/Alias | |
Gene Name | SAS4 |
Gene Synonyms/Alias | YDR181C; YD9395.15C |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 23 | RLLRSEIKNSHGEFE | acetylation | [1] | | 181 | VTLQKVTKINDPTDE | acetylation | [1] | | 413 | ISPTLSEKAPLGSIS | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Component of the SAS complex, a multiprotein complex that acetylates 'Lys-16' of histone H4 and 'Lys-14' of histone H3. The SAS complex is however unable to acetylate nucleosomal histones. The complex is involved in transcriptional silencing at telomeres and at HML locus. Also involved in rDNA silencing. In the complex, SAS4 is essential for histone acetyltransferase (HAT) activity of the complex. |
Sequence Annotation | |
Keyword | Chromatin regulator; Coiled coil; Complete proteome; Nucleus; Reference proteome; Repressor; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 481 AA |
Protein Sequence | MGIFQSIEEA NNTSERLLRS EIKNSHGEFE KFDFDTEEYE INPKRKLRLV SRINPNAGHL 60
RKSKSCFTVD EHVDETRCQK PVMKSPFMSN VDDEIKKKRE TITKMTLEIE HHELSQNIRK 120
PTDDLLPDST YQPYHKKMLK QENRMIQSDI VNGENEADRL SLISDRLGML NWEVTLQKVT 180
KINDPTDENE METKRYQTKE LIDSMLHKFE SMKKKSRNLA RRPASSDSLL KLVSGKDWPK 240
IYTRIDRTFI PDYASSSDEE EEKITVEEIR ERRLKKREQQ CGGSIIVLLS DHQSQKGMTR 300
FAIVAEPLRK PYLIKTSTKE RNSWKNKVPT NPKKFKKAPR ISTQIAVKRR REVIPLTMEV 360
EPEVIRDIRQ DTQKSMKLNV KAEEISVTET VKSKEMNALR NNAASISPTL SEKAPLGSIS 420
SCTASQISQR SSENVGAIIN NINPNLAIVP SCNEKTFVKT HNGMKTNSGI NILPVRKKKK 480
V 481 |
Gene Ontology | GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro. GO:0000790; C:nuclear chromatin; IDA:SGD. GO:0000784; C:nuclear chromosome, telomeric region; IC:SGD. GO:0033255; C:SAS acetyltransferase complex; IDA:SGD. GO:0004402; F:histone acetyltransferase activity; IDA:SGD. GO:0006348; P:chromatin silencing at telomere; IDA:SGD. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |