UniProt Accession

 RLMH_ECOLI; P0A8I8; P05850 

Genbank Protein ID

 X04516; U82598; U00096; AP009048 

Genbank Nucleotide ID

 CAA28200.1; AAB40836.1; AAC73737.1; BAA35283.1 

Protein Name

 Ribosomal RNA large subunit methyltransferase H 

Protein Synonyms/Alias

 23S rRNA (pseudouridine1915-N3)-methyltransferase; 23S rRNA m3Psi1915 methyltransferase; rRNA (pseudouridine-N3-)-methyltransferase RlmH 

Gene Name

 rlmH 

Gene Synonyms/Alias

 ybeA; b0636; JW0631 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
29	EYLRRFPKDMPFELI	acetylation	[1]
55	DIKRILDKEGEQMLA	acetylation	[1]
77	VTLDIPGKPWDTPQL	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA. Specific for fully assembled 70S ribosomes. 

Sequence Annotation

  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Methyltransferase; Reference proteome; rRNA processing; S-adenosyl-L-methionine; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 155 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IC:UniProtKB.
 GO:0042803; F:protein homodimerization activity; NAS:UniProtKB.
 GO:0043022; F:ribosome binding; NAS:UniProtKB.
 GO:0070038; F:rRNA (pseudouridine-N3-)-methyltransferase activity; IMP:UniProtKB.
 GO:0070475; P:rRNA base methylation; IMP:EcoCyc. 

Interpro

 IPR016051; RlmH.
 IPR003742; SPOUT_MeTrfase. 

Pfam

 PF02590; SPOUT_MTase 

SMART

  

PROSITE

  

PRINTS