CPLM-009700

Genbank Nucleotide ID

High mobility group protein B1

Protein Synonyms/Alias

Amphoterin; Heparin-binding protein p30; High mobility group protein 1; HMG-1

Rattus norvegicus (Rat)

Position	Peptide	Type	References
114	SEYRPKIKGEHPGLS	ubiquitination	[1]

[1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]

Functional Description

DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells (By similarity).

DNA_BIND 9 79 HMG box 1.
DNA_BIND 95 163 HMG box 2.
MOD_RES 30 30 N6-acetyllysine (By similarity).
MOD_RES 35 35 Phosphoserine (By similarity).
MOD_RES 100 100 Phosphoserine (By similarity).
CROSSLNK 112 112 Glycyl lysine isopeptide (Lys-Gly)

3D-structure; Acetylation; Chromosome; Complete proteome; Cytoplasm; Direct protein sequencing; DNA-binding; Heparin-binding; Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome; Repeat; Ubl conjugation.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
GO:0005737; C:cytoplasm; IDA:RGD.
GO:0005615; C:extracellular space; IDA:RGD.
GO:0005634; C:nucleus; IDA:RGD.
GO:0008097; F:5S rRNA binding; IDA:RGD.
GO:0003681; F:bent DNA binding; IDA:MGI.
GO:0000402; F:crossed form four-way junction DNA binding; IDA:MGI.
GO:0005125; F:cytokine activity; IDA:UniProtKB.
GO:0008301; F:DNA binding, bending; IDA:RGD.
GO:0003690; F:double-stranded DNA binding; IDA:RGD.
GO:0051861; F:glycolipid binding; IDA:RGD.
GO:0008201; F:heparin binding; IDA:RGD.
GO:0000401; F:open form four-way junction DNA binding; IDA:MGI.
GO:0042277; F:peptide binding; IDA:RGD.
GO:0046983; F:protein dimerization activity; IDA:RGD.
GO:0050786; F:RAGE receptor binding; IMP:RGD.
GO:0003697; F:single-stranded DNA binding; IDA:RGD.
GO:0008134; F:transcription factor binding; IDA:RGD.
GO:0031532; P:actin cytoskeleton reorganization; IMP:RGD.
GO:0000902; P:cell morphogenesis; IMP:RGD.
GO:0071347; P:cellular response to interleukin-1; IEP:RGD.
GO:0006935; P:chemotaxis; IDA:RGD.
GO:0007623; P:circadian rhythm; IEP:RGD.
GO:0032392; P:DNA geometric change; IDA:MGI.
GO:0050930; P:induction of positive chemotaxis; IDA:MGI.
GO:0050831; P:male-specific defense response to bacterium; IDA:RGD.
GO:0051450; P:myoblast proliferation; IMP:RGD.
GO:0008156; P:negative regulation of DNA replication; IDA:RGD.
GO:0031175; P:neuron projection development; IGI:UniProtKB.
GO:0002053; P:positive regulation of mesenchymal cell proliferation; IDA:MGI.
GO:0045931; P:positive regulation of mitotic cell cycle; IDA:MGI.
GO:0033034; P:positive regulation of myeloid cell apoptotic process; IDA:RGD.
GO:0045663; P:positive regulation of myoblast differentiation; IMP:RGD.
GO:0010976; P:positive regulation of neuron projection development; IMP:RGD.
GO:0014911; P:positive regulation of smooth muscle cell migration; IMP:RGD.
GO:0050727; P:regulation of inflammatory response; IDA:RGD.
GO:0042493; P:response to drug; IEP:RGD.
GO:0009749; P:response to glucose stimulus; IEP:RGD.
GO:0009408; P:response to heat; IEP:RGD.
GO:0032868; P:response to insulin stimulus; IEP:RGD.
GO:0034341; P:response to interferon-gamma; IMP:RGD.
GO:0032496; P:response to lipopolysaccharide; IEP:RGD.

IPR009071; HMG_box_dom.
IPR017967; HMG_boxA_CS.

PF09011; DUF1898
PF00505; HMG_box

PS00353; HMG_BOX_1
PS50118; HMG_BOX_2