CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001594
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phosphoacetylglucosamine mutase 
Protein Synonyms/Alias
 PAGM; Acetylglucosamine phosphomutase; N-acetylglucosamine-phosphate mutase; Phosphoglucomutase-3; PGM 3 
Gene Name
 PGM3 
Gene Synonyms/Alias
 AGM1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
8MDLGAITKYSALHAKubiquitination[1, 2, 3]
177NTGGRYGKATIEGYYubiquitination[4, 5]
186TIEGYYQKLSKAFVEubiquitination[5]
189GYYQKLSKAFVELTKubiquitination[4]
196KAFVELTKQASCSGDubiquitination[5]
209GDEYRSLKVDCANGIubiquitination[5]
244FNDGSKGKLNHLCGAubiquitination[5]
343RYLEEVMKVPVYCTKubiquitination[5]
350KVPVYCTKTGVKHLHubiquitination[5]
388TAVEMKIKQSAEQLEubiquitination[4]
397SAEQLEDKKRKAAKMubiquitination[4]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Interconverts GlcNAc-6-P and GlcNAc-1-P. 
Sequence Annotation
 ACT_SITE 64 64 Phosphoserine intermediate.
 METAL 64 64 Magnesium; via phosphate group (By
 METAL 276 276 Magnesium (By similarity).
 METAL 278 278 Magnesium (By similarity).
 METAL 280 280 Magnesium (By similarity).
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 64 64 Phosphoserine.  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Isomerase; Magnesium; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 542 AA 
Protein Sequence
MDLGAITKYS ALHAKPNGLI LQYGTAGFRT KAEHLDHVMF RMGLLAVLRS KQTKSTIGVM 60
VTASHNPEED NGVKLVDPLG EMLAPSWEEH ATCLANAEEQ DMQRVLIDIS EKEAVNLQQD 120
AFVVIGRDTR PSSEKLSQSV IDGVTVLGGQ FHDYGLLTTP QLHYMVYCRN TGGRYGKATI 180
EGYYQKLSKA FVELTKQASC SGDEYRSLKV DCANGIGALK LREMEHYFSQ GLSVQLFNDG 240
SKGKLNHLCG ADFVKSHQKP PQGMEIKSNE RCCSFDGDAD RIVYYYHDAD GHFHLIDGDK 300
IATLISSFLK ELLVEIGESL NIGVVQTAYA NGSSTRYLEE VMKVPVYCTK TGVKHLHHKA 360
QEFDIGVYFE ANGHGTALFS TAVEMKIKQS AEQLEDKKRK AAKMLENIID LFNQAAGDAI 420
SDMLVIEAIL ALKGLTVQQW DALYTDLPNR QLKVQVADRR VISTTDAERQ AVTPPGLQEA 480
INDLVKKYKL SRAFVRPSGT EDVVRVYAEA DSQESADHLA HEVSLAVFQL AGGIGERPQP 540
GF 542 
Gene Ontology
 GO:0005829; C:cytosol; IBA:RefGenome.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0004610; F:phosphoacetylglucosamine mutase activity; IDA:UniProtKB.
 GO:0006488; P:dolichol-linked oligosaccharide biosynthetic process; TAS:Reactome.
 GO:0006041; P:glucosamine metabolic process; NAS:UniProtKB.
 GO:0030097; P:hemopoiesis; IBA:RefGenome.
 GO:0043687; P:post-translational protein modification; TAS:Reactome.
 GO:0018279; P:protein N-linked glycosylation via asparagine; TAS:Reactome.
 GO:0006048; P:UDP-N-acetylglucosamine biosynthetic process; IBA:RefGenome. 
Interpro
 IPR005844; A-D-PHexomutase_a/b/a-I.
 IPR016055; A-D-PHexomutase_a/b/a-I/II/III.
 IPR005845; A-D-PHexomutase_a/b/a-II.
 IPR005843; A-D-PHexomutase_C.
 IPR016066; A-D-PHexomutase_CS.
 IPR016657; PAGM. 
Pfam
 PF02878; PGM_PMM_I
 PF02879; PGM_PMM_II
 PF00408; PGM_PMM_IV 
SMART
  
PROSITE
 PS00710; PGM_PMM 
PRINTS