UniProt Accession

 HEM3_MOUSE; P22907; Q3TIV0 

Genbank Protein ID

 M28666; M28663; M28664; M28665; M28666; M28663; M28664; M28665; AK166734; AK167702 

Genbank Nucleotide ID

 AAA39890.1; AAA39890.1; AAA39890.1; AAA39890.1; AAA39891.1; AAA39891.1; AAA39891.1; AAA39891.1; BAE38979.1; BAE39746.1 

Protein Name

 Porphobilinogen deaminase 

Protein Synonyms/Alias

 PBG-D; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase 

Gene Name

 Hmbs 

Gene Synonyms/Alias

 Uros1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
70	ILDTALSKIGEKSLF	ubiquitination	[1]
74	ALSKIGEKSLFTKEL	acetylation	[2, 3]
79	GEKSLFTKELENALE	ubiquitination	[1]
128	DAVVFHPKFIGKTLE	ubiquitination	[1]
132	FHPKFIGKTLETLPE	acetylation	[4]
140	TLETLPEKSAVGTSS	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. 

Sequence Annotation

 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 261 261 S-(dipyrrolylmethanemethyl)cysteine (By  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Heme biosynthesis; Porphyrin biosynthesis; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 361 AA 

Protein Sequence

Gene Ontology

 GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
 GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.
 GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway. 

Interpro

 IPR000860; 4pyrrol_synth_OHMeBilane_synth.
 IPR022419; Porphobilin_deaminase_cofac_BS.
 IPR022417; Porphobilin_deaminase_N.
 IPR022418; Porphobilinogen_deaminase_C. 

Pfam

 PF01379; Porphobil_deam
 PF03900; Porphobil_deamC 

SMART

  

PROSITE

 PS00533; PORPHOBILINOGEN_DEAM 

PRINTS

 PR00151; PORPHBDMNASE.