CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014604
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Hematopoietic progenitor cell antigen CD34 
Protein Synonyms/Alias
 CD34 
Gene Name
 Cd34 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
349ASPETQGKANVTRGAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins (By similarity). 
Sequence Annotation
 MOD_RES 326 326 Phosphotyrosine.
 MOD_RES 336 336 Phosphotyrosine.
 CARBOHYD 50 50 N-linked (GlcNAc...) (Potential).
 CARBOHYD 56 56 N-linked (GlcNAc...) (Potential).
 CARBOHYD 87 87 N-linked (GlcNAc...) (Potential).
 CARBOHYD 137 137 N-linked (GlcNAc...) (Potential).
 CARBOHYD 144 144 N-linked (GlcNAc...) (Potential).
 CARBOHYD 145 145 N-linked (GlcNAc...) (Potential).
 CARBOHYD 246 246 N-linked (GlcNAc...).  
Keyword
 Alternative splicing; Cell adhesion; Complete proteome; Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 382 AA 
Protein Sequence
MQVHRDTRAG LLLPWRWVAL CLMSLLHLNN LTSATTETST QGISPSVPTN ESVEENITSS 60
IPGSTSHYLI YQDSSKTTPA ISETMVNFTV TSGIPSGSGT PHTFSQPQTS PTGILPTTSD 120
SISTSEMTWK SSLPSINVSD YSPNNSSFEM TSPTEPYAYT SSSAPSAIKG EIKCSGIREV 180
RLAQGICLEL SEASSCEEFK KEKGEDLIQI LCEKEEAEAD AGASVCSLLL AQSEVRPECL 240
LMVLANSTEL PSKLQLMEKH QSDLRKLGIQ SFNKQDIGSH QSYSRKTLIA LVTSGVLLAI 300
LGTTGYFLMN RRSWSPTGER LGEDPYYTEN GGGQGYSSGP GASPETQGKA NVTRGAQENG 360
TGQATSRNGH SARQHVVADT EL 382 
Gene Ontology
 GO:0016324; C:apical plasma membrane; ISS:UniProtKB.
 GO:0009925; C:basal plasma membrane; ISS:UniProtKB.
 GO:0009897; C:external side of plasma membrane; IDA:MGI.
 GO:0036053; C:glomerular endothelium fenestra; ISS:UniProtKB.
 GO:0045171; C:intercellular bridge; ISS:UniProtKB.
 GO:0005764; C:lysosome; ISS:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
 GO:0030246; F:carbohydrate binding; ISS:UniProtKB.
 GO:0043199; F:sulfate binding; IDA:MGI.
 GO:0008283; P:cell proliferation; ISS:UniProtKB.
 GO:0016337; P:cell-cell adhesion; ISS:UniProtKB.
 GO:0001935; P:endothelial cell proliferation; IEA:Compara.
 GO:0003158; P:endothelium development; IEA:Compara.
 GO:0071971; P:extracellular vesicular exosome assembly; IEA:Compara.
 GO:0072011; P:glomerular endothelium development; IEA:Compara.
 GO:0003094; P:glomerular filtration; ISS:UniProtKB.
 GO:0006536; P:glutamate metabolic process; ISS:UniProtKB.
 GO:0071425; P:hematopoietic stem cell proliferation; IEA:Compara.
 GO:0050900; P:leukocyte migration; IMP:MGI.
 GO:0035759; P:mesangial cell-matrix adhesion; ISS:UniProtKB.
 GO:0072254; P:metanephric glomerular mesangial cell differentiation; IEA:Compara.
 GO:0030195; P:negative regulation of blood coagulation; ISS:UniProtKB.
 GO:1900035; P:negative regulation of cellular response to heat; ISS:UniProtKB.
 GO:1900038; P:negative regulation of cellular response to hypoxia; ISS:UniProtKB.
 GO:0010629; P:negative regulation of gene expression; IEA:Compara.
 GO:1900041; P:negative regulation of interleukin-2 secretion; IEA:Compara.
 GO:0060547; P:negative regulation of necrotic cell death; ISS:UniProtKB.
 GO:0045019; P:negative regulation of nitric oxide biosynthetic process; ISS:UniProtKB.
 GO:0032720; P:negative regulation of tumor necrosis factor production; ISS:UniProtKB.
 GO:0038001; P:paracrine signaling; IEA:Compara.
 GO:0045766; P:positive regulation of angiogenesis; ISS:UniProtKB.
 GO:0010628; P:positive regulation of gene expression; IEA:Compara.
 GO:1900168; P:positive regulation of glial cell line-derived neurotrophic factor secretion; IEA:Compara.
 GO:0071657; P:positive regulation of granulocyte colony-stimulating factor production; IEA:Compara.
 GO:0032733; P:positive regulation of interleukin-10 production; ISS:UniProtKB.
 GO:0042482; P:positive regulation of odontogenesis; ISS:UniProtKB.
 GO:0071636; P:positive regulation of transforming growth factor beta production; ISS:UniProtKB.
 GO:2001214; P:positive regulation of vasculogenesis; ISS:UniProtKB.
 GO:0008217; P:regulation of blood pressure; ISS:UniProtKB.
 GO:0007165; P:signal transduction; IEA:Compara.
 GO:0001894; P:tissue homeostasis; ISS:UniProtKB.
 GO:0060290; P:transdifferentiation; IEA:Compara.
 GO:0061042; P:vascular wound healing; IEA:Compara. 
Interpro
 IPR008083; CD34.
 IPR013836; CD34/Podocalyxin. 
Pfam
 PF06365; CD34_antigen 
SMART
  
PROSITE
  
PRINTS
 PR01700; CD34ANTIGEN.