| Tag | Content |
|---|
| CPLM ID | CPLM-013425 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Cyclin-L1 |
Protein Synonyms/Alias | Cyclin-L; Cyclin Ania-6a |
Gene Name | Ccnl1 |
Gene Synonyms/Alias | Ania6a; Ccn1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 365 | SPVSINVKTVKKEPE | acetylation | [1] | | 365 | SPVSINVKTVKKEPE | succinylation | [1] |
|
Reference | [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways. Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y. Mol Cell. 2013 Jun 27;50(6):919-30. [ PMID: 23806337] |
Functional Description | Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Seems to be involved in the regulation of RNA polymerase II (pol II). Functions in association with cyclin-dependent kinases (CDKs). Inhibited by the CDK-specific inhibitor p21 (By similarity). |
Sequence Annotation | REGION 94 196 Cyclin-like 1.
REGION 209 293 Cyclin-like 2.
REGION 396 438 RS.
MOD_RES 331 331 Phosphothreonine (By similarity).
MOD_RES 341 341 Phosphoserine (By similarity).
MOD_RES 344 344 Phosphoserine (By similarity).
MOD_RES 358 358 Phosphoserine (By similarity).
MOD_RES 451 451 Phosphoserine (By similarity). |
Keyword | Alternative splicing; Complete proteome; Cyclin; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 532 AA |
Protein Sequence | MASGPHPTST AAAAAAAAAS ASSAAPSAGG SSSGTTTTTT TTTGGILIGD RLYSEVSLTI 60
DHSLIPEERL SPTPSMQDGL DLPSETDLRI LGCELIQAAG ILLRLPQVAM ATGQVLFHRF 120
FYSKSFVKHS FEIVAMACIN LASKIEEAPR RIRDVINVFH HLRQLRGKRT PSPLILDQNY 180
INTKNQVIKA ERRVLKELGF CVHVKHPHKI IVMYLQVLEC ERNQTLVQTA WNYMNDSLRT 240
NVFVRFQPET IACACIYLAA RALQIPLPTR PHWFLLFGTT EEEIQEICIE TLRLYTRKKP 300
NYELLEKEVE KRKVALQEAK LKAKGLNLDG TPALSTLGGF SPASKPSSPR EVKAEEKSPV 360
SINVKTVKKE PEDRQQASKS PYNGVRKDSK RSRTSRSASR SRSRTRSRSR SHSPRRHYNN 420
RRSRSGTYSS RSRSRSRSHS ESPRRHHNHG SPHLKAKHTR EDLKSSNRHG HKRKKSRSRS 480
QSKTRDHSDV TKKHRHERGH HRDRRERSRS FERSHKGKHH GGSRSGHGRH RR 532 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell. GO:0008023; C:transcription elongation factor complex; ISA:MGI. GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IEA:InterPro. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006396; P:RNA processing; IEA:InterPro. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |