CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016646
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Fibronectin type-III domain-containing protein 3A 
Protein Synonyms/Alias
  
Gene Name
 Fndc3a 
Gene Synonyms/Alias
 D14Ertd453e; Fndc3; Kiaa0970 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
384PRIANRTKNSLTLQWacetylation[1]
528EDLAYTVKNLRRSTKubiquitination[2]
539RSTKYKFKVIAYNSEubiquitination[2]
Reference
 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Mediates spermatid-Sertoli adhesion during spermatogenesis. 
Sequence Annotation
 DOMAIN 265 365 Fibronectin type-III 1.
 DOMAIN 371 462 Fibronectin type-III 2.
 DOMAIN 467 558 Fibronectin type-III 3.
 DOMAIN 564 657 Fibronectin type-III 4.
 DOMAIN 661 754 Fibronectin type-III 5.
 DOMAIN 758 848 Fibronectin type-III 6.
 DOMAIN 849 947 Fibronectin type-III 7.
 DOMAIN 951 1042 Fibronectin type-III 8.
 DOMAIN 1047 1143 Fibronectin type-III 9.
 MOD_RES 207 207 Phosphoserine.
 MOD_RES 213 213 Phosphoserine (By similarity).
 MOD_RES 384 384 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Complete proteome; Golgi apparatus; Membrane; Phosphoprotein; Reference proteome; Repeat; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1198 AA 
Protein Sequence
MAEHPPLLDT AQILSSDISL LSAPIVSADG TQQVILVQVN PGEAFTIRRE DGQFQCITGP 60
AQVPMMSPNG SVPPIYVPPG YAPQVIEDNG VRRVVVVPQS PEFHPGGHTV IHRSPHPPLP 120
GFIPVPTMMP PPPRHMYSPV TGAGDMATQY MPQYQSSQVY ADVDAHSTHG RSNFRDERSS 180
KTYERLQKKL KDRQGTQKDK MSSPPPSPQK CPSPISEHNG LIKGQNASGG NTGSARNRSG 240
RGRSCTQVDP EMEEKDEETK AFEAFLSNIV KPVASDIQAR TVLLTWSPPS SFINGEVNET 300
AVPELFNYEV LVSSTGKEGK YRSVYIGEET SVTLNDLKPA TDYHAKVQAE SNSIKGIPSE 360
AESFTTLSCE PDPPNAPRIA NRTKNSLTLQ WKAPSDNGSK IQSFILEWDE GKGNGEFCQC 420
YMGSQKQFKI TKLSPAMGCK FRLSAKNDYG VSDFSEEVLY YTSGCAPSVP ASPVLTKAGV 480
TWLSLQWTKP SGTPSDEGIS YILEMEEETS GYGFKPKYDG EDLAYTVKNL RRSTKYKFKV 540
IAYNSEGKSN PSEVVEFSTC PDKPGVPVKP SVKGKIHSHG FKITWDPPKD NGGAPINKYV 600
VEMAEGSNGN KWDMIYSGTT REHLCDRLTP GCYYRLRVYC ISDGGQSAVS ESLLVQTPAV 660
PPGPCLPPRL QGRPKAKEIQ LRWGPPQVDG GSPISCYAVE MTPADKDEPR DVYQGSEVEC 720
TVGSLLPGKT YSFRLRAANR IGFGPFSEKY DITTAPGPPD QCRPPQVTCR SATCAQVNWE 780
IPLSNGTDVT EYRLEWGGVE GSMQMCYCGP GLSCELKGLS PATTYYCRVQ AMSVVGAGPF 840
SEVVACVTPP SVPAIVTCLQ EISDDDIEYP HYSPSTCLAI SWKEPYDHGS EILAYSIDLG 900
DKQPLTVGKM TSYIIDSLQP DTTYRIRIQA LNSLGAGPFS HTIKLKTKPL PPDPPRLECV 960
AFNHQNLKLK WGEGTPKTLS TDAVQYHLQM EDRNGRFVSL YRGPCHTYKV QRLSESTSYK 1020
FCIQACNEAG EGPLSQEYVF TTPKSLPAAL KAPKIEKIND HICEITWEYL QPMKGDPVIY 1080
NLQVMVGKDS EFKQIYKGPD TSFRYSSLQL NCEYRFRVCA IRQCQDPTGH QDLVGPYSTT 1140
VFFISQRTEP PASSNKDSVD SARTRRTLSD EQCAAVILVV FAFFSILIAF IIQYFVIK 1198 
Gene Ontology
 GO:0001669; C:acrosomal vesicle; IDA:MGI.
 GO:0005829; C:cytosol; IDA:MGI.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0012506; C:vesicle membrane; IDA:MGI.
 GO:0016337; P:cell-cell adhesion; IMP:MGI.
 GO:0009566; P:fertilization; IMP:MGI.
 GO:0060009; P:Sertoli cell development; IMP:MGI.
 GO:0007286; P:spermatid development; IMP:MGI. 
Interpro
 IPR003961; Fibronectin_type3.
 IPR013783; Ig-like_fold. 
Pfam
 PF00041; fn3 
SMART
 SM00060; FN3 
PROSITE
 PS50853; FN3 
PRINTS