| Tag | Content |
|---|
| CPLM ID | CPLM-013115 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Activating transcription factor 7-interacting protein 2 |
Protein Synonyms/Alias | MBD1-containing chromatin-associated factor 2; Protein similar to MCAF2 |
Gene Name | Atf7ip2 |
Gene Synonyms/Alias | Mcaf2; Psm2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 53 | IPNGHNQKMFSKNKE | phosphoglycerylation | [1] |
|
Reference | [1] Functional lysine modification by an intrinsically reactive primary glycolytic metabolite. Moellering RE, Cravatt BF. Science. 2013 Aug 2;341(6145):549-53. [ PMID: 23908237] |
Functional Description | Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. The complex formed with MBD1 and SETDB1 represses transcription and probably couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) activity (By similarity). |
Sequence Annotation | DOMAIN 347 444 Fibronectin type-III. |
Keyword | Activator; Alternative splicing; Complete proteome; Nucleus; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 452 AA |
Protein Sequence | MESPDRKRQK VLKAKKTMPT SYQKQLEILN KSTNVEAPKT TVGTNIPNGH NQKMFSKNKE 60
NVKVMKVSEQ INENACGALE RHTALLEQVK HWIRQEICMI NCNLFDKKLN ELNERIGKTQ 120
CKSRHEAIAG ELFVKIRRLQ KRIKTVLSSQ RNCLEPNTLP SNTVCKVTDS EAMNLNVTQK 180
SVKSRSKRIS SVNHTPLNSS EKAGRKTNLP STCVEFASES NTDDVMLISV KNSNLTTSIT 240
SEQTEIRKNT SRNLSNSPNS MIKVGPVEKK FDFVIDLTRE GPSNYSIESP SFTLKSTSKA 300
VLRSKEIIPV AENGNEGFGS FEHLPPLPEP PAPLPEMADK IKDTLPPQKP ELKVKWVLRP 360
TSIALTWNIP KVNPNCAPVE SYHLFLYYEN SDHLTWKKIA EIKALPLPMA CTLSQNLAST 420
KYYFAVQSKD IFGRYGPFCN IKSIPRFSEN LT 452 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:Compara. GO:0005730; C:nucleolus; IEA:Compara. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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Pfam | |
SMART | |
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