UniProt Accession

 SODM_RAT; P07895 

Genbank Protein ID

 Y00497; X56600; BC070913 

Genbank Nucleotide ID

 CAA68549.1; CAA39937.1; AAH70913.1 

Protein Name

 Superoxide dismutase [Mn], mitochondrial 

Protein Synonyms/Alias

  

Gene Name

 Sod2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
53	IMQLHHSKHHATYVN	acetylation	[1]
68	NLNVTEEKYHEALAK	acetylation	[1]
75	KYHEALAKGDVTTQV	acetylation	[1]
89	VALQPALKFNGGGHI	acetylation	[1]
108	FWTNLSPKGGGEPKG	acetylation	[1]
114	PKGGGEPKGELLEAI	acetylation	[1]
122	GELLEAIKRDFGSFE	acetylation	[1]
130	RDFGSFEKFKEKLTA	acetylation	[1]
132	FGSFEKFKEKLTAVS	acetylation	[1]
134	SFEKFKEKLTAVSVG	acetylation	[1]
202	NVRPDYLKAIWNVIN	acetylation	[1]
221	SQRYIVCKK******	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. 

Sequence Annotation

 METAL 50 50 Manganese (By similarity).
 METAL 98 98 Manganese (By similarity).
 METAL 183 183 Manganese (By similarity).
 METAL 187 187 Manganese (By similarity).
 MOD_RES 58 58 Nitrated tyrosine.
 MOD_RES 68 68 N6-acetyllysine (By similarity).
 MOD_RES 130 130 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; Manganese; Metal-binding; Mitochondrion; Nitration; Oxidoreductase; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 222 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; IEA:Compara.
 GO:0042645; C:mitochondrial nucleoid; IDA:RGD.
 GO:0003677; F:DNA binding; IDA:RGD.
 GO:0042802; F:identical protein binding; IDA:RGD.
 GO:0030145; F:manganese ion binding; ISS:UniProtKB.
 GO:0019825; F:oxygen binding; IDA:RGD.
 GO:0004784; F:superoxide dismutase activity; ISS:UniProtKB.
 GO:0001315; P:age-dependent response to reactive oxygen species; ISS:UniProtKB.
 GO:0071361; P:cellular response to ethanol; IEP:RGD.
 GO:0003032; P:detection of oxygen; IEA:Compara.
 GO:0048773; P:erythrophore differentiation; IEA:Compara.
 GO:0006749; P:glutathione metabolic process; IEA:Compara.
 GO:0007507; P:heart development; IEA:Compara.
 GO:0030097; P:hemopoiesis; IEA:Compara.
 GO:0050665; P:hydrogen peroxide biosynthetic process; IDA:RGD.
 GO:0055072; P:iron ion homeostasis; IEA:Compara.
 GO:0001889; P:liver development; IEA:Compara.
 GO:0007626; P:locomotory behavior; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IMP:RGD.
 GO:0045599; P:negative regulation of fat cell differentiation; IEA:Compara.
 GO:0048147; P:negative regulation of fibroblast proliferation; IEA:Compara.
 GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Compara.
 GO:0048666; P:neuron development; IEA:Compara.
 GO:0032364; P:oxygen homeostasis; IEA:Compara.
 GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Compara.
 GO:0009791; P:post-embryonic development; IEA:Compara.
 GO:0051260; P:protein homooligomerization; IDA:RGD.
 GO:0051289; P:protein homotetramerization; IEA:Compara.
 GO:0050790; P:regulation of catalytic activity; IEA:Compara.
 GO:0051881; P:regulation of mitochondrial membrane potential; IEA:Compara.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
 GO:0001836; P:release of cytochrome c from mitochondria; IEA:Compara.
 GO:0019430; P:removal of superoxide radicals; IDA:RGD.
 GO:0022904; P:respiratory electron transport chain; IEA:Compara.
 GO:0014823; P:response to activity; IEP:RGD.
 GO:0048678; P:response to axon injury; IEA:Compara.
 GO:0046686; P:response to cadmium ion; IEP:RGD.
 GO:0042493; P:response to drug; IDA:RGD.
 GO:0051602; P:response to electrical stimulus; IEP:RGD.
 GO:0010332; P:response to gamma radiation; IEA:Compara.
 GO:0042542; P:response to hydrogen peroxide; IEP:RGD.
 GO:0055093; P:response to hyperoxia; IEA:Compara.
 GO:0001666; P:response to hypoxia; IEP:RGD.
 GO:0033591; P:response to L-ascorbic acid; IEP:RGD.
 GO:0032496; P:response to lipopolysaccharide; IEP:RGD.
 GO:0010042; P:response to manganese ion; IEP:RGD.
 GO:0010269; P:response to selenium ion; IEP:RGD.
 GO:0034021; P:response to silicon dioxide; IEP:RGD.
 GO:0010043; P:response to zinc ion; IEP:RGD.
 GO:0042554; P:superoxide anion generation; IEA:Compara.
 GO:0003069; P:vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure; IEA:Compara. 

Interpro

 IPR001189; Mn/Fe_SOD.
 IPR019833; Mn/Fe_SOD_BS.
 IPR019832; Mn/Fe_SOD_C.
 IPR019831; Mn/Fe_SOD_N. 

Pfam

 PF02777; Sod_Fe_C
 PF00081; Sod_Fe_N 

SMART

  

PROSITE

 PS00088; SOD_MN 

PRINTS

 PR01703; MNSODISMTASE.