UniProt Accession

 GATM_RAT; P50442; Q6ITZ7 

Genbank Protein ID

 U07971; BC081785; AY625271 

Genbank Nucleotide ID

 AAA21250.1; AAH81785.1; AAT39897.1 

Protein Name

 Glycine amidinotransferase, mitochondrial 

Protein Synonyms/Alias

 L-arginine:glycine amidinotransferase; Transamidinase 

Gene Name

 Gatm 

Gene Synonyms/Alias

 Agat 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
102	VKANTYEKYWPFYQK	acetylation	[1]
109	KYWPFYQKNGGLYFP	acetylation	[1]
117	NGGLYFPKDHLKKAV	acetylation	[1]
121	YFPKDHLKKAVAEVE	acetylation	[1]
152	DPIDWSLKYKTPDFE	acetylation	[1]
154	IDWSLKYKTPDFEST	acetylation	[1]
201	RAYRSIIKDYFHRGA	acetylation	[1]
209	DYFHRGAKWTTAPKP	acetylation	[1]
381	ANEVPIQKMFEKLGI	acetylation	[1]
385	PIQKMFEKLGISTIK	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development. Also capable of catalyzing the synthesis of a range of neuroactive guanidino compounds by utilizing alternative amidine donors and acceptors for the transamidination reaction. 

Sequence Annotation

 ACT_SITE 254 254 By similarity.
 ACT_SITE 303 303 By similarity.
 ACT_SITE 407 407 Amidino-cysteine intermediate (By
 MOD_RES 385 385 N6-acetyllysine (By similarity).
 MOD_RES 417 417 Phosphothreonine (By similarity).  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; Membrane; Mitochondrion; Mitochondrion inner membrane; Phosphoprotein; Reference proteome; Transferase; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 423 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
 GO:0005758; C:mitochondrial intermembrane space; IEA:Compara.
 GO:0015067; F:amidinotransferase activity; IDA:RGD.
 GO:0015068; F:glycine amidinotransferase activity; IEA:EC.
 GO:0016813; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines; IEA:InterPro.
 GO:0006601; P:creatine biosynthetic process; TAS:RGD.
 GO:0009790; P:embryo development; IEP:RGD.
 GO:0046689; P:response to mercury ion; IDA:RGD.
 GO:0007584; P:response to nutrient; IDA:RGD.
 GO:0006979; P:response to oxidative stress; IEP:RGD.
 GO:0043434; P:response to peptide hormone stimulus; IDA:RGD.
 GO:0042246; P:tissue regeneration; IEP:RGD. 

Interpro

 IPR003198; Amidino_trans. 

Pfam

 PF02274; Amidinotransf 

SMART

  

PROSITE

  

PRINTS