CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033135
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Zinc finger CCCH-type antiviral protein 1 
Protein Synonyms/Alias
  
Gene Name
 ZC3HAV1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
12EVCCFITKILCAHGGubiquitination[1, 2, 3]
76RARVCRRKYCQRPCDubiquitination[2, 3]
89CDNLHLCKLNLLGRCubiquitination[2]
107QSERNLCKYSHEVLSubiquitination[1, 2]
119VLSEENFKVLKNHELubiquitination[1, 2]
197SHNLMDRKVLAIMREubiquitination[2]
296PVDDLTRKFTYLGSQubiquitination[2]
360STSAPNWKSLTSWTNubiquitination[1]
401PEAVTTRKGTGLLSSubiquitination[2]
641ICLDHLCKGCPLNGSubiquitination[2]
751GEEKDKRKNSNVDSSubiquitination[2]
892ENSELLDKFTWKKSQubiquitination[2]
905SQMKEEGKLLFYATSubiquitination[4, 5, 6, 7]
944GKGIYFAKDAIYSHKubiquitination[2]
951KDAIYSHKNCPYDAKubiquitination[2]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [6] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [7] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1024 AA 
Protein Sequence
MADPEVCCFI TKILCAHGGR MALDALLQEI ALSEPQLCEV LQVAGPDRFV VLETGGEAGI 60
TRSVVATTRA RVCRRKYCQR PCDNLHLCKL NLLGRCNYSQ SERNLCKYSH EVLSEENFKV 120
LKNHELSGLN KEELAVLLLQ SDPFFMPEIC KSYKGEGRQQ ICNQQPPCSR LHICDHFTRG 180
NCRFPNCLRS HNLMDRKVLA IMREHGLNPD VVQNIQDICN SKHMQKNPPG PRAPSSHRRN 240
MAYRARSKSR DRFFQGSQEF LASASASAER SCTPSPDQIS HRASLEDAPV DDLTRKFTYL 300
GSQDRARPPS GSSKATDLGG TSQAGTSQRF LENGSQEDLL HGNPGSTYLA SNSTSAPNWK 360
SLTSWTNDQG ARRKTVFSPT LPAARSSLGS LQTPEAVTTR KGTGLLSSDY RIINGKSGTQ 420
DIQPGPLFNN NADGVATDIT STRSLNYKST SSGHREISSP RIQDAGPASR DVQATGRIAD 480
DADPRVALVN GKYKGKTLWA STFVHDIPNG SSQVVDKTTD VEKTGATGFG LTMAVKAEKD 540
MLRTGSQSLR NLVPTTPGES TAPAQVSTLP QSPAALSSSN RAAVWGAQGQ NCTQVPVSSA 600
SELTRKTTGS AQYSLSDVTS TTSSRVDDHD SEEICLDHLC KGCPLNGSCS KVHFHLPYRW 660
QMLIGKTWTD FEHMETIEKG YCNPGIHLCS VGSYTINFRV MSCDSFPIRR LSTPSSVTKP 720
ANSVFTTKWI WYWKNESGTW IQYGEEKDKR KNSNVDSSYL ESLYQSCPRG VVPFQAGSRN 780
YELSFQGMIQ TNIASKTQKD VIRRPTFVPQ WYVQQMKRGP DHQPAKTSSV SLTATFRPQE 840
DFCFLSSKKY KLSEIHHLHP EYVRVSEHFK ASMKNFKIEK IKKIENSELL DKFTWKKSQM 900
KEEGKLLFYA TSRAYVESIC SNNFDSFLHE THENKYGKGI YFAKDAIYSH KNCPYDAKNV 960
VMFVAQVLVG KFTEGNITYT SPPPQFDSCV DTRSNPSVFV IFQKDQVYPQ YVIEYTEDKA 1020
CVIS 1024 
Gene Ontology
 GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IEA:InterPro.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR012317; Poly(ADP-ribose)pol_cat_dom.
 IPR004170; WWE-dom.
 IPR000571; Znf_CCCH. 
Pfam
 PF00644; PARP 
SMART
  
PROSITE
 PS51059; PARP_CATALYTIC
 PS50918; WWE
 PS50103; ZF_C3H1 
PRINTS