CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006048
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tricarboxylate transport protein, mitochondrial 
Protein Synonyms/Alias
 Citrate transport protein; CTP; Solute carrier family 25 member 1; Tricarboxylate carrier protein 
Gene Name
 Slc25a1 
Gene Synonyms/Alias
 Slc20a3 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
149PMETVKVKFIHDQTSacetylation[1]
190GLTATVLKQGSNQAIacetylation[1]
255MQGLEAHKYRNTLDCacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Involved in citrate-H(+)/malate exchange. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway. 
Sequence Annotation
 REPEAT 23 111 Solcar 1.
 REPEAT 122 208 Solcar 2.
 REPEAT 218 303 Solcar 3.  
Keyword
 Complete proteome; Direct protein sequencing; Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Repeat; Transit peptide; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 311 AA 
Protein Sequence
MAAPRAPRAL TAAAPGSGKA KLTHPGKAIL AGGLAGGIEI CITFPTEYVK TQLQLDERAN 60
PPRYRGIGDC VRQTVRSHGV LGLYRGLSSL LYGSIPKAAV RFGMFEFLSN HMRDAQGRLD 120
SRRGLLCGLG AGVAEAVVVV CPMETVKVKF IHDQTSSNPK YRGFFHGVRE IVREQGLKGT 180
YQGLTATVLK QGSNQAIRFF VMTSLRNWYQ GDNPNKPMNP LITGVFGAVA GAASVFGNTP 240
LDVIKTRMQG LEAHKYRNTL DCGVQILKNE GPKAFYKGTV PRLGRVCLDV AIVFVIYDEV 300
VKLLNKVWKT D 311 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
 GO:0015137; F:citrate transmembrane transporter activity; TAS:RGD.
 GO:0006843; P:mitochondrial citrate transport; TAS:RGD. 
Interpro
 IPR002067; Mit_carrier.
 IPR018108; Mitochondrial_sb/sol_carrier.
 IPR023395; Mt_carrier_dom. 
Pfam
 PF00153; Mito_carr 
SMART
  
PROSITE
 PS50920; SOLCAR 
PRINTS
 PR00926; MITOCARRIER.