UniProt Accession

 RCOR3_HUMAN; Q9P2K3; B3KYA2; B4DYY7; Q5VT47; Q7L9I5; Q8N5U3; Q9NV83 

Genbank Protein ID

 AB037764; AK131312; AK302664; AK001738; AL590101; AL611964; AL590101; AL611964; AL611964; AL590101; AL611964; AL590101; BC031608 

Genbank Nucleotide ID

 BAA92581.1; BAG54764.1; BAG63899.1; BAA91872.1; CAH72432.1; CAH72432.1; CAH72433.1; CAH72433.1; CAH73871.1; CAH73871.1; CAH73872.1; CAH73872.1; AAH31608.1 

Protein Name

 REST corepressor 3 

Protein Synonyms/Alias

  

Gene Name

 RCOR3 

Gene Synonyms/Alias

 KIAA1343 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
78	EFDPGATKYTDKDNG	ubiquitination	[1]
183	KTIASLVKYYYSWKK	ubiquitination	[2]
383	NKTVGQVKNFFVNYR	ubiquitination	[1, 3]

Reference

 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 May act as a component of a corepressor complex that represses transcription (Potential). 

Sequence Annotation

 DOMAIN 1 83 ELM2.
 DOMAIN 84 135 SANT 1.
 DOMAIN 285 336 SANT 2.
 MOD_RES 156 156 Phosphoserine.  

Keyword

 Alternative splicing; Coiled coil; Complete proteome; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 495 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003682; F:chromatin binding; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR000949; ELM2_dom.
 IPR009057; Homeodomain-like.
 IPR001005; SANT/Myb.
 IPR017884; SANT_dom. 

Pfam

 PF01448; ELM2
 PF00249; Myb_DNA-binding 

SMART

 SM00717; SANT 

PROSITE

 PS51156; ELM2
 PS51293; SANT 

PRINTS