UniProt Accession

 NXS1_NAJOX; P01427 

Genbank Protein ID

  

Genbank Nucleotide ID

  

Protein Name

 Short neurotoxin 1 

Protein Synonyms/Alias

 Neurotoxin II; NTX II; Neurotoxin alpha 

Gene Name

  

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Naja oxiana (Central Asian cobra) (Oxus cobra) 

NCBI Taxa ID

 8657 

Lysine Modification

Position	Peptide	Type	References
15	SSQPPTTKTCSGETN	acetylation	[1]
25	SGETNCYKKWWSDHR	acetylation	[1]
26	GETNCYKKWWSDHRG	acetylation	[1]
44	ERGCGCPKVKPGVNL	acetylation	[1]
46	GCGCPKVKPGVNLNC	acetylation	[1]

Reference

 [1] Conformational studies of neurotoxin II from Naja naja oxiana. Selective N-acylation, circular dichroism and nuclear-magnetic-resonance study of acylation products.
 Tsetlin VI, Arseniev AS, Utkin YN, Gurevich AZ, Senyavina LB, Bystrov VF, Ivanov VT, Ovchinnikov YA.
 Eur J Biochem. 1979 Mar;94(2):337-46. [PMID: 34515] 

Functional Description

 Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site. Binds to the muscular nicotinic acetylcholine receptor. 

Sequence Annotation

 DISULFID 3 23
 DISULFID 17 40
 DISULFID 42 53
 DISULFID 54 59  

Keyword

 3D-structure; Acetylcholine receptor inhibiting toxin; Direct protein sequencing; Disulfide bond; Ion channel impairing toxin; Neurotoxin; Postsynaptic neurotoxin; Secreted; Toxin. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 61 AA 

Protein Sequence

Gene Ontology

 GO:0035792; C:other organism postsynaptic membrane; IEA:UniProtKB-KW.
 GO:0035821; P:modification of morphology or physiology of other organism; IEA:InterPro. 

Interpro

 IPR003571; Snake_toxin.
 IPR018354; Snake_toxin_BS. 

Pfam

 PF00087; Toxin_1 

SMART

  

PROSITE

 PS00272; SNAKE_TOXIN 

PRINTS